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Research ArticleResearch

Two-Year Randomized Clinical Trial of Adjunctive Minocycline Microspheres in Periodontal Maintenance

Amy C. Killeen, Jennifer A. Harn, Jeffrey Jensen, Fang Yu, Shawn Custer and Richard A. Reinhardt
American Dental Hygienists' Association August 2018, 92 (4) 51-58;
Amy C. Killeen
DDS, MS
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  • For correspondence: [email protected]
Jennifer A. Harn
RDH, BS
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Jeffrey Jensen
DDS, MS
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Fang Yu
PhD
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Shawn Custer
BS
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Richard A. Reinhardt
DDS, PhD
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  • Article
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    Figure 1.

    Randomization flow chart

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    Figure 2.

    Application of MM into test site

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    Figure 3.

    Interproximal alveolar bone height from cementoenamel junction at test and control sites

    mean ± standard deviation

    No significant differences were noted between groups or time points.

  • Figure 4.
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    Figure 4.

    Probing depth and clinical attachment loss at test and control sites

    mean ± standard deviation

    A significant reduction in both measurements was noted between baseline and 24 months for both groups.

    No significant differences noted between groups.

  • Figure 5.
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    Figure 5.

    Percent bleeding on probing at test and control sites

  • Figure 6.
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    Figure 6.

    Log transformed IL-1β in test and control site gingival crevicular fluid or saliva

    mean ± standard deviation

    No significant differences were noted between groups or time points.

Tables

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    Table I.

    Patient Demographics

    Table I.
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In this issue

American Dental Hygienists' Association: 92 (4)
American Dental Hygienists' Association
Vol. 92, Issue 4
August 2018
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Two-Year Randomized Clinical Trial of Adjunctive Minocycline Microspheres in Periodontal Maintenance
Amy C. Killeen, Jennifer A. Harn, Jeffrey Jensen, Fang Yu, Shawn Custer, Richard A. Reinhardt
American Dental Hygienists' Association Aug 2018, 92 (4) 51-58;

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Two-Year Randomized Clinical Trial of Adjunctive Minocycline Microspheres in Periodontal Maintenance
Amy C. Killeen, Jennifer A. Harn, Jeffrey Jensen, Fang Yu, Shawn Custer, Richard A. Reinhardt
American Dental Hygienists' Association Aug 2018, 92 (4) 51-58;
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Keywords

  • Periodontal disease
  • periodontal pockets
  • non-surgical periodontal therapy
  • periodontal maintenance
  • scaling and root planning
  • chemotherapeutics

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