Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Archived Issues
  • Info for
    • Authors
    • Advertisements
    • Subscribing
  • About
    • About Us
    • Editorial Board
    • JDH Reviewers
  • More
    • Alerts
    • Feedback
    • Permissions

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
Journal of Dental Hygiene

Visit the American Dental Hygienists' Association's main website

  • Register
  • Subscribe
  • My alerts
  • Log in
Journal of Dental Hygiene

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Archived Issues
  • Info for
    • Authors
    • Advertisements
    • Subscribing
  • About
    • About Us
    • Editorial Board
    • JDH Reviewers
  • More
    • Alerts
    • Feedback
    • Permissions
  • Visit jdenthyg on Facebook
  • Follow jdenthyg on Twitter
  • Follow jdenthyg on Instagram
  • Follow jdenthyg on Linkedin
  • RSS feeds
Case ReportCase Study

The Care and Management of Bisphosphonate – Associated Osteonecrosis of the Jaw in the Patient with Multiple Myeloma: A Case Study

Melvin J. Teah, Sheryl L. Ernest Syme, Mark Scheper and Dianna S. Weikel
American Dental Hygienists' Association August 2013, 87 (4) 181-187;
Melvin J. Teah
RDH, BS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sheryl L. Ernest Syme
RDH, MS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Scheper
DDS, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dianna S. Weikel
RDH, MS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. ↵
    1. Hose D,
    2. Rème T,
    3. Hielscher T,
    4. et al
    . Proliferation is a central independent prognostic factor and target for personalized and risk–adapted treatment in multiple myeloma. Haematologica. 2011;96(1):87–95.
    OpenUrlAbstract/FREE Full Text
  2. ↵
    Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment: Health Professional Version. National Cancer Institute [Internet]. [cited 2011 April 4]. Available from: http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/Patient
  3. ↵
    1. Goldman L,
    2. Bennett CL
    1. Kyle RA
    . Plasma cell disorder: Hematologic Diseases. In: Goldman L, Bennett CL. Cecil Textbook of Medicine. 21st ed. Philadelphia: WB Saunders Company; 2000. p. 977–980.
  4. ↵
    1. American Dental Association Council on Scientific Affairs
    . Professionally applied topical fluoride: Evidence–based clinical recommendations. J Am Dent Assoc. 2006;137(8):1151–1159.
    OpenUrlAbstract/FREE Full Text
  5. ↵
    1. Walter C,
    2. Al–Nawas B,
    3. Frickhofen N,
    4. et al
    . Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients. Head Face Med. 2010;6:11.
    OpenUrlPubMed
  6. ↵
    What you need to know about multiple myeloma. National Cancer Institute [Internet]. [cited 2008 Nov 16]. Available from: http://www.cancer.gov/cancertopics/wyntk/myeloma
  7. ↵
    1. Vieira–Leite–Segundo A,
    2. Lima Falcão MF,
    3. Correia–Lins Filho R,
    4. Marques Soares MS,
    5. López López J,
    6. Chimenos Küstner E
    . Multiple Myeloma with primary manifestation in the mandible: A case report. Med Oral Patol Oral Cir Bucal. 2008;13(4):232–234.
    OpenUrl
  8. ↵
    1. Ruggiero SL,
    2. Dodson TB,
    3. Assael LA,
    4. et al
    . American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate–related osteonecrosis of the jaws––2009 update. J Oral Maxillofac Surg. 2009;67(5):2–12.
    OpenUrlPubMedWeb of Science
  9. ↵
    1. Pickett FA,
    2. American Academy of Oral Medicine
    . Bisphosphonate–associated osteonecrosis of the jaw: A literature review and clinical practice guidelines. J Dent Hyg. 2006;80(3):10.
    OpenUrlFREE Full Text
  10. ↵
    1. Badros A,
    2. Weikel D,
    3. Salama A,
    4. et al
    . Osteonecrosis of the jaw in multiple myeloma patients: Clinical features and risk factors. J Clin Oncol. 2006:24(6):945–952.
    OpenUrlAbstract/FREE Full Text
  11. ↵
    1. Migliorati CA,
    2. Casiglia J,
    3. Epstein J,
    4. Jacobsen PL,
    5. Siegel MA,
    6. Woo SB
    . Managing the care of patients with bisphosphonate–associated osteonecrosis. An American Academy of Oral Medicine position paper. J Am Dent Assoc. 2005;136(12):1658–1668.
    OpenUrlAbstract/FREE Full Text
  12. ↵
    1. Walter C,
    2. Al–Nawas B,
    3. Grötz KA,
    4. et al
    . Prevalence and risk factors of bisphosphonate–associated osteonecrosis of the jaw in prostate cancer patients with advanced disease treated with zoledronate. Eur Urol. 2008;54(5):1066–1072.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Bagan JV,
    2. Jimenez Y,
    3. Murillo J,
    4. et al
    . Jaw osteonecrosis associated with bisphosphonates: multiple exposed areas and its relationship to teeth extractions. Study of 20 cases. Oral Oncol. 2006;42(3):327–329.
    OpenUrlCrossRefPubMedWeb of Science
    1. Bamias A,
    2. Kastritis E,
    3. Bamia C,
    4. et al
    . Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol. 2005;23(34):8580–8587
    OpenUrlAbstract/FREE Full Text
    1. Mavrokokki T,
    2. Cheng A,
    3. Stien B,
    4. Goss A
    . Nature and frequency of bisphosphonate–associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surg. 2007;65(3):415–423
    OpenUrlCrossRefPubMedWeb of Science
    1. Woo SB,
    2. Hellstein JW,
    3. Kalmar JR
    : Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 2006;144(10):753–761.
    OpenUrlCrossRefPubMedWeb of Science
  14. ↵
    1. Aragon–Ching JB,
    2. Ning YM,
    3. Chen CC,
    4. et al
    . Higher incidence of osteonecrosis of the jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with anti–angiogenic agents. Cancer Invest. 2009;27(2):221–226.
    OpenUrlCrossRefPubMedWeb of Science
    1. Boonyapakorn T,
    2. Schirmer I,
    3. Reichart PA,
    4. Sturm I,
    5. Massenkeil G
    . Bisphosphonate–induced osteonecrosis of the jaws: prospective study of 80 patients with multiple myeloma and other malignancies. Oral Oncol. 2008;44(9):857–869.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Advisory Task Force on Bisphosphonate–Related Ostenonecrosis of the Jaws,
    2. American Association of Oral and Maxillofacial Surgeons
    . American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate–related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65(3):369–376.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. Borrás–Blasco J,
    2. Rosique–Robles D,
    3. Giner–Marco V,
    4. Galan–Brotons A,
    5. Casterá E,
    6. Costa S
    . Possible delayed onset of osteonecrosis of the jaw in association with zoledronic acid. A case report. J Clin Pharm Ther. 2007;32(6):651–654.
    OpenUrlCrossRefPubMed
  17. ↵
    1. Goffinet M,
    2. Thoulouzan M,
    3. Pradines A,
    4. et al
    . Zoledronic acid treatment impairs protein geranyl–geranylation for biological effects in prostatic cells. BMC Cancer. 2006;6:60.
    OpenUrlCrossRefPubMed
    1. Luckman SP,
    2. Hughes DE,
    3. Coxon FP,
    4. Graham R,
    5. Russell G,
    6. Rogers MJ
    . Nitrogen–containing bisphosphonates inhibit the mevalonate pathway and prevent post–translational prenylation of GTP–binding proteins, including ras. J Bone Miner Res. 1998;13(4):581–589
    OpenUrlCrossRefPubMedWeb of Science
    1. Sedghizadeh PP,
    2. Kumar SK,
    3. Gorur A,
    4. Schaudinn C,
    5. Shuler CF,
    6. Costerton JW
    . Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy. J Oral Maxillofac Surg. 2008;66(4):767–775.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Weitzman R,
    2. Sauter N,
    3. Eriksen EF,
    4. et al
    . Critical review: updated recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in cancer patients––May 2006. Crit Rev Oncol Hematol. 2007;62(2):148–152.
    OpenUrlCrossRefPubMedWeb of Science
  19. ↵
    1. Taylor KH,
    2. Middlefell LS,
    3. Mizen KD
    . Osteonecrosis of the jaws induced by anti–RANK ligand therapy. Br J Oral Maxillofac Surg. 48(3):221–223.
    1. Kyrgidis A,
    2. Toulis KA
    . Denosumab–related osteonecrosis of the jaws. Osteoporos Int. 2011;22(1):369–370.
    OpenUrlCrossRefPubMed
    1. Aghaloo TL,
    2. Felsenfeld AL,
    3. Tetradis S
    . Osteonecrosis of the jaw in a patient on Denosumb. J Oral Maxillofac Surg. 2010;68(5):959–963.
    OpenUrlCrossRefPubMedWeb of Science
    1. Migliorati CA,
    2. Covington JS 3rd.
    . New oncology drugs and osteonecrosis of the jaw (ONJ). J Tenn Dent Assoc. 2009;89(4):36–38.
    OpenUrlPubMed
  20. ↵
    1. Estilo CL,
    2. Fornier M,
    3. Farooki A,
    4. Carlson D,
    5. Bohle G 3rd.,
    6. Huryn JM
    . Osteonecrosis of the jaw related to bevacizumab. J Clin Oncol. 2008;26(24):4037–4038.
    OpenUrlFREE Full Text
  21. ↵
    1. Hellstein JW,
    2. Adler RA,
    3. Edwards B,
    4. et al
    . Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2011;142(11):1243–1251.
    OpenUrlAbstract/FREE Full Text
  22. ↵
    1. Ripamonti CI,
    2. Maniezzo M,
    3. Campa T,
    4. et al
    . Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. Ann Oncol. 2009;20(1):137–145.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Dimopoulos MA,
    2. Kastritis E,
    3. Bamia C,
    4. et al
    . Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Ann Oncol. 2009;20(1):117–120.
    OpenUrlAbstract/FREE Full Text
  24. ↵
    1. Khosla S,
    2. Burr D,
    3. Cauley J,
    4. et al
    . Bisphosphonate–Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007;22(10):1479–1491.
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Dental Hygienists Association: 87 (4)
American Dental Hygienists' Association
Vol. 87, Issue 4
August 2013
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Dental Hygiene.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Care and Management of Bisphosphonate – Associated Osteonecrosis of the Jaw in the Patient with Multiple Myeloma: A Case Study
(Your Name) has sent you a message from Journal of Dental Hygiene
(Your Name) thought you would like to see the Journal of Dental Hygiene web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
The Care and Management of Bisphosphonate – Associated Osteonecrosis of the Jaw in the Patient with Multiple Myeloma: A Case Study
Melvin J. Teah, Sheryl L. Ernest Syme, Mark Scheper, Dianna S. Weikel
American Dental Hygienists' Association Aug 2013, 87 (4) 181-187;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The Care and Management of Bisphosphonate – Associated Osteonecrosis of the Jaw in the Patient with Multiple Myeloma: A Case Study
Melvin J. Teah, Sheryl L. Ernest Syme, Mark Scheper, Dianna S. Weikel
American Dental Hygienists' Association Aug 2013, 87 (4) 181-187;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • Introduction
    • Case Report
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Similar Articles

More in this TOC Section

  • DIY Orthodontic Relapse Correction Gone Wrong: A case study
Show more Case Study

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Keywords

  • Bisphosphonate
  • osteonecrosis of the jaw
  • zoledronic acid

About

  • About ADHA
  • About JDH
  • JDH Reviewers
  • Contact Us

Helpful Links

  • Submit a Paper
  • Author Guidelines
  • Permissions
  • FAQs

More Information

  • Advertise
  • Subscribe
  • Email Alerts
  • Help

ISSN #: 1553-0205

Copyright © 2025 American Dental Hygienists’ Association

Powered by HighWire