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Research ArticleArticles

Locally Delivered Antimicrobials: Clinical Evidence and Relevance

David W. Paquette, Maria Emanuel Ryan and Rebecca S. Wilder
American Dental Hygienists' Association October 2008, 82 (suppl 2) 10-15;
David W. Paquette
DMD, MPH, DMSc
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Maria Emanuel Ryan
DDS, PhD
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Rebecca S. Wilder
RDH, BS, MS
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References

    1. Albandar J,
    2. Brunelle JA,
    3. Kingman A
    . Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol 1999;70:13-29.
    OpenUrlCrossRefPubMedWeb of Science
    1. Flemmig TF
    . Periodontitis. Ann Periodontol 1999;4:32-38.
    OpenUrlCrossRefPubMed
    1. Socransky SS,
    2. Haffajee AD
    . Periodontal microbial ecology. Periodontol 2000 2005;38:135-187.
    OpenUrlCrossRefPubMedWeb of Science
    1. Offenbacher S
    . Periodontal diseases: pathogenesis. Ann Periodontol 1996;1:821-878.
    OpenUrlCrossRefPubMed
    1. Socransky SS,
    2. Haffajee AD,
    3. Goodson JM,
    4. Lindhe J
    . New concepts of destructive periodontal disease. J Clin Periodontol 1984; 11:21-32.
    OpenUrlCrossRefPubMedWeb of Science
  1. American Academy of Periodontology Research, Science and Therapy Committee. Tobacco use and the periodontal patient. J Periodontol 1999;70: 1419-1427.
    OpenUrlCrossRefPubMedWeb of Science
    1. Grossi SG,
    2. Genco RJ
    . Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol 1998;3:51-61.
    OpenUrlCrossRefPubMed
    1. Saito T,
    2. Shimazaki Y,
    3. Sakamoto M
    . Obesity and periodontitis. N Eng J Med. 1998;482-483.
    1. Ramfjord SP,
    2. Morrison EC,
    3. Burgett FG,
    4. Nissle RR,
    5. Shick RA,
    6. Zann GJ,
    7. Knowles JW
    . Oral hygiene and maintenance of periodontal support. J Periodontol 1982;53:26-30.
    OpenUrlPubMed
    1. Kornman KS,
    2. Crane A,
    3. Wang HY,
    4. di Giovine FS,
    5. Newman MG,
    6. Pirk FW,
    7. Wilson TG Jr.,
    8. et al
    . The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997;24:72-77.
    OpenUrlCrossRefPubMedWeb of Science
    1. Halazonetis TD,
    2. Haffajee AD,
    3. Socransky SS
    . Relationship of clinical parameters to attachment loss in subsets of subjects with destructive periodontal diseases. J Clin Periodontol 1989;16:563-568.
    OpenUrlPubMed
    1. Paulander J,
    2. Axelsson P,
    3. Lindhe J,
    4. Wennstrom J
    . Intra-oral pattern of tooth and periodontal bone loss between the age of 50 and 60 years. A longitudinal prospective study. Acta Odontol Scand 2004;62:214-222.
    OpenUrlPubMed
  2. American Academy of Periodontology. Parameter on chronic periodontitis with slight to moderate loss of periodontal support. J Periodontol 2000;71:853-855.
    OpenUrlPubMed
  3. American Academy of Periodontology. Parameter on chronic periodontitis with advanced loss of periodontal support. J Periodontol 2000;71:856-858.
    OpenUrlCrossRefPubMed
    1. Cobb CM
    . Non-surgical pocket therapy: Mechanical. Ann Periodontol 1996;1:450-490.
    OpenUrl
    1. Palcanis KG
    . Surgical pocket therapy. Ann Periodontol 1996;1:589-606.
    OpenUrlCrossRefPubMed
    1. Drisko CH
    . Nonsurgical pocket therapy: Pharmacotherapeutics. Ann Periodontol 1996;1:491-566.
    OpenUrlPubMed
    1. Hanes PJ,
    2. Purvis JP,
    3. Gunsolley JC
    . Local anti-infective therapy: pharmacological agents. A systematic review. Ann Periodontol 2003;8:79-98.
    OpenUrlPubMed
    1. Goodson JM,
    2. Holborow D,
    3. Dunn RL,
    4. Hogan P,
    5. Dunham S
    . Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets. J Periodontol 1983; 54:575-579.
    OpenUrlPubMed
    1. Soskolne WA,
    2. Chajek T,
    3. Flashner M,
    4. Landau I,
    5. Stabholtz A,
    6. Kolatch B,
    7. Lerner EI
    . An in vivo study of the chlorhexidine release profile of the PerioChip in the gingival crevicular fluid, plasma and urine. J Clin Periodontol 1998;25:1017-1021.
    OpenUrlPubMed
    1. Stabholz A,
    2. Sela MN,
    3. Friedman M,
    4. Golomb G,
    5. Soskolne A
    . Clinical and microbiological effects of sustained release chlorhexidine in periodontal pockets. J Clin Periodontol 1986;13:783-788.
    OpenUrlPubMed
    1. Jeffcoat MK,
    2. Bray KS,
    3. Ciancio SG,
    4. Dentino AR,
    5. Fine DH,
    6. Gordon JM,
    7. et al
    . Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol 1998;69:989-997.
    OpenUrlPubMedWeb of Science
    1. Jeffcoat MK,
    2. Palcanis KG,
    3. Weatherford TW,
    4. Reese M,
    5. Geurs NC,
    6. Flashner M
    . Use of a biodegradable chlorhexidine chip in the treatment of adult periodontitis: clinical and radiographic findings. J Periodontol 2000;71:256-262.
    OpenUrlPubMed
    1. Stoller NH,
    2. Johnson LR,
    3. Trapnell S,
    4. Harrold CQ,
    5. Garrett S
    . The pharmacokinetic profile of a biodegradable controlledrelease delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva, and serum. J Periodontol 1998;69:1085-91.
    OpenUrlCrossRefPubMed
    1. Walker CB,
    2. Godowski KC,
    3. Borden L,
    4. Lennon J,
    5. Nango S,
    6. Stone C,
    7. et al
    . The effects of sustained release doxycycline on the anaerobic flora and antibiotic-resistant patterns in subgingival plaque and saliva. J Periodontol 2000;71:768-774.
    OpenUrlPubMed
    1. Garrett S,
    2. Johnson L,
    3. Drisko CH,
    4. Adams DF,
    5. Bandt C,
    6. Beiswanger B,
    7. et al
    . Two multi-center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol 1999;70:490-503.
    OpenUrlPubMed
    1. Ryder MI,
    2. Pons B,
    3. Adams D,
    4. Beiswanger B,
    5. Blanco V,
    6. Bogle G,
    7. et al
    . Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing. J Clin Periodontol 1999;26:683-691.
    OpenUrlPubMed
    1. Wennstrom JL,
    2. Newman HN,
    3. MacNeill SR,
    4. Killoy WJ,
    5. Griffiths GS,
    6. Gillam DG,
    7. et al
    . Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches. J Clin Periodontol 2001;28:753-761.
    OpenUrlCrossRefPubMed
    1. Oringer RJ,
    2. Al-Shammari KF,
    3. Aldredge WA,
    4. Iacono VJ,
    5. Eber RM,
    6. Wang HL,
    7. Berwald B,
    8. et al
    . Effects of locally delivered minocycline microspheres on markers of bone resorption. J Periodontol 2002;73:835-842.
    OpenUrlCrossRefPubMed
    1. Williams R,
    2. Paquette D,
    3. Offenbacher S,
    4. Adams D,
    5. Armitage G,
    6. Bray K,
    7. et al.
    , Treatment of periodontitis by local administration of minocycline microspheres: a controlled trial. J Periodontol 2001;72:1535-1544.
    OpenUrlCrossRefPubMedWeb of Science
    1. Paquette DW,
    2. Oringer R,
    3. Lessem J,
    4. Offenbacher S,
    5. Genco R,
    6. Persson GR,
    7. Williams R
    . Locally delivered minocycline microspheres for the treatment of periodontitis in smokers. J Clin Periodontol 2003;30:787-794.
    OpenUrlPubMed
    1. Paquette DW
    . Pocket depth reduction as an outcome measure of inflammation and soft tissue changes in Periodontitis trials. J Int Acad Periodontol 2005;7/4 (Supplement):147-156.
    OpenUrl
    1. Paquette DW,
    2. Williams RC,
    3. Hanlon A,
    4. Lessem J
    . Clinical relevance of adjunctive minocycline microspheres in patients with chronic periodontitis: secondary analysis of a phase 3 trial. J Periodontol 2004;75:531-536.
    OpenUrlPubMed
    1. Lessem J,
    2. Hanlon A
    . A post-marketing study of 2805 patients treated for periodontal disease with Arestin. J Int Acad Periodontol 2004;6:150-153.
    OpenUrlPubMed
    1. Hellström MK,
    2. McClain PK,
    3. Schallhorn RG,
    4. Bellis L,
    5. Hanlon AL,
    6. Ramberg P
    . Local minocycline as an adjunct to surgical therapy in moderate to severe, chronic periodontitis. J Clin Periodontol 2008;35:525-31.
    OpenUrlPubMed
    1. Renvert S,
    2. Lessem J,
    3. Dahlén G,
    4. Lindahl C,
    5. Svensson M
    . Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: a randomized clinical trial. J Clin Periodontol 2006;33:362-9.
    OpenUrlPubMed
    1. Renvert S,
    2. Lessem J,
    3. Dahlén G,
    4. Renvert H,
    5. Lindahl C
    . Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial. J Periodontol 2008;79:836-44.
    OpenUrlPubMed
    1. Salvi GE,
    2. Persson GR,
    3. Heitz-Mayfield LJ,
    4. Frei M,
    5. Lang NP
    . Adjunctive local antibiotic therapy in the treatment of periimplantitis II: clinical and radiographic outcomes. Clin Oral Implants Res 2007;18:281-5.
    OpenUrlPubMed
    1. Persson GR,
    2. Salvi GE,
    3. Heitz-Mayfield LJ,
    4. Lang NP
    . Antimicrobial therapy using a local drug delivery system (Arestin) in the treatment of peri-implantitis. I: Microbiological outcomes. Clin Oral Implants Res 2006;17:386-93.
    OpenUrlPubMed
    1. Goodson JM,
    2. Gunsolley JC,
    3. Grossi SG,
    4. Bland PS,
    5. Otomo-Corgel J,
    6. Doherty F,
    7. Comiskey J
    . Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy.J Periodontol. 2007;78:1568-79.
    OpenUrlPubMed
    1. Oringer RJ,
    2. Al-Shammari KF,
    3. Aldredge WA,
    4. Iacono VJ,
    5. Eber RM,
    6. Wang HL,
    7. et al
    . Effects of locally delivered minocycline microspheres on markers of bone resorption. J Periodontol. 2002; 73:835-842.
    OpenUrlCrossRefPubMed
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Locally Delivered Antimicrobials: Clinical Evidence and Relevance
David W. Paquette, Maria Emanuel Ryan, Rebecca S. Wilder
American Dental Hygienists' Association Oct 2008, 82 (suppl 2) 10-15;

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Locally Delivered Antimicrobials: Clinical Evidence and Relevance
David W. Paquette, Maria Emanuel Ryan, Rebecca S. Wilder
American Dental Hygienists' Association Oct 2008, 82 (suppl 2) 10-15;
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Keywords

  • periodontitis
  • antibiotics
  • antimicrobials
  • local delivery
  • periimplantitis
  • scaling and root planing

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