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Research ArticleShort communication

Genes Underlying Familial Hypodontia: A Review and Discussion of the Role of Dental Hygienists in Future Research

Maria L Nino-Rosales and Pragna I Patel
American Dental Hygienists' Association June 2005, 79 (3) 10;
Maria L Nino-Rosales
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Pragna I Patel
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References

    1. Bath-Balogh M,
    2. Fehrenbach MJ,
    3. Thomas P,
    4. Kaszczuk S
    . .. Illustrated dental embryology, histology, and anatomy. Philadelphia (PA): W.B. Saunders; 1997. 62-82.
    1. Avery JK,
    2. Steele PF
    . Essentials of oral histology and embryology: a clinical approach. St. Louis (MO): Mosby; 2000. 51-68.
    1. Thesleff I,
    2. Keranen S,
    3. Jernvall J
    . Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation. Adv Dent Res. 2001. Aug;15: 14-8.
    OpenUrlAbstract/FREE Full Text
    1. Champlin TL,
    2. Mallory SB
    . Hypohidrotic ectodermal dysplasia: a review. J Ark Med Soc. 1989;86(3): 115-7 .
    OpenUrlPubMed
    1. Beierle LE,
    2. Jorgenson RJ
    . Anodontia in a child: report of case. ASDC J Dent Child. 1978;45(6): 483-7.
    OpenUrlPubMed
    1. Arte S,
    2. Nieminen P,
    3. Apajalahti S,
    4. Haavikko K,
    5. Thesleff I,
    6. Pirinen S
    . Characteristics of incisor-premolar hypodontia in families. J Dent Res. 2001;80(5): 1445-1450.
    OpenUrlAbstract/FREE Full Text
    1. Stevenson RE,
    2. Hall JG,
    3. Goodman RM
    . Human malformations and related anomalies No 27. Oxford (UK): Oxford University Press; 1993. 383-396.
    1. Jorgenson RJ,
    2. Levin LS,
    3. Cross HE,
    4. Yoder F,
    5. Kelly TE
    . The Rieger syndrome. Am J Med Genet. 1978;2(3): 307-318.
    OpenUrlCrossRefPubMedWeb of Science
    1. Peck S,
    2. Peck L,
    3. Kataja M
    . Prevalence of tooth agenesis and peg-shaped maxillary lateral incisor associated with palatally displaced canine (PDC) anomaly. Am J Orthod Dentofacial Orthop. 1996;110(4): 441-3.
    OpenUrlCrossRefPubMedWeb of Science
    1. Peck S,
    2. Peck L,
    3. Kataja M
    . Concomitant occurrence of canine malposition and tooth agenesis: evidence of orofacial genetic fields. Am J Orthod Dentofacial Orthop. 2002;122(6): 657-660.
    OpenUrlCrossRefPubMedWeb of Science
    1. Jorgenson RJ
    . Clinician's view of hypodontia. J Am Dent Assoc. 1980;101(2): 283-6.
    OpenUrlAbstract
    1. Vastardis H
    . The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop. 2000;117(6): 650-6.
    OpenUrlPubMedWeb of Science
    1. Patel PI
    . Identification of disease genes and somatic gene therapy: an overview and prospects for the aged. J Gerontol. 1993;48(3): B80-5.
    OpenUrlAbstract/FREE Full Text
    1. Slagboom PE,
    2. Meulenbelt I
    . Organisation of the human genome and our tools for identifying disease genes. Biol Psychol. 2002;61(1-2): 11-31.
    OpenUrlPubMed
    1. Elston RC
    . Linkage and association to genetic markers. Exp Clin Immunogenet. 1995;12(3): 129-140.
    OpenUrlPubMedWeb of Science
    1. Hoh JJ,
    2. Ott J
    . Complex inheritance and localizing disease genes. Hum Hered. 2000;50(1): 85-9.
    OpenUrlPubMed
    1. Thesleff I,
    2. Aberg T
    . Molecular regulation of tooth development. Bone. 1999;25(1): 123-5.
    OpenUrlCrossRefPubMed
    1. Thesleff I
    . Genetic basis of tooth development and dental defects. Acta Odontol Scand. 2000;58(5): 191-4.
    OpenUrlCrossRefPubMedWeb of Science
    1. Peters H,
    2. Balling R
    . Teeth: where and how to make them. Trends Genet. 1999;15(2): 59-65.
    OpenUrlCrossRefPubMedWeb of Science
    1. Thesleff I,
    2. Aberg T
    . Molecular regulation of tooth development. Bone. 1999;25(1): 123-5.
    OpenUrlCrossRefPubMed
    1. Kratochwil K,
    2. Dull M,
    3. Farinas I,
    4. Galceran J,
    5. Grosschedl R
    . Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev. 1996;10(11): 1382-1394.
    OpenUrlAbstract/FREE Full Text
    1. Qiu M,
    2. Bulfone A,
    3. Ghattas I,
    4. Meneses JJ,
    5. Christensen L,
    6. Sharpe PT,
    7. Presley R,
    8. Pedersen RA,
    9. Rubenstein JL
    . Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997;185(2): 165-184.
    OpenUrlCrossRefPubMedWeb of Science
    1. Vastardis H,
    2. Karimbux N,
    3. Guthua SW,
    4. Seidman JG,
    5. Seidman CE
    . A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet. 1996;13(4): 417-421.
    OpenUrlCrossRefPubMedWeb of Science
    1. Stockton DW,
    2. Das P,
    3. Goldenberg M,
    4. D'Souza RN,
    5. Patel PA
    . Mutation of PAX9 is associated with oligodontia. Nat Genet. 2000;24(1): 18-9.
    OpenUrlCrossRefPubMedWeb of Science
    1. Liu W,
    2. Wang H,
    3. Zhao S,
    4. Zhao W,
    5. Bai S,
    6. Zhao Y,
    7. Xu S,
    8. Wu C,
    9. Huang W,
    10. Chen Z,
    11. Feng G,
    12. He L
    . The novel gene locus for agenesis of permanent teeth (He-Zhao deficiency) maps to chromosome 10q11.2. J Dent Res. 2001;80(8): 1716-20.
    OpenUrlAbstract/FREE Full Text
    1. Mina M
    . Morphogenesis of the medial region of the developing mandible is regulated by multiple signaling pathways. Cells Tissues Organs. 2001;169(3): 295-301.
    OpenUrlPubMed
    1. Lidral AC,
    2. Reising BC
    . The role of MSX1 in human tooth agenesis. J Dent Res. 2002;81(4): 274-8.
    OpenUrlAbstract/FREE Full Text
    1. Chen Y,
    2. Bei M,
    3. Woo I,
    4. Satokata I,
    5. Maas R
    . Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996;122(10): 3035-3044.
    OpenUrlAbstract
    1. Satokata I,
    2. Maas R
    . Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet. 1994;6(4): 348-356.
    OpenUrlCrossRefPubMedWeb of Science
    1. Orestes-Cardoso S,
    2. Nefussi JR,
    3. Lezot F,
    4. Oboeuf M,
    5. Pereira M,
    6. Mesbah M,
    7. Robert B,
    8. Berdal A
    . Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model. Connect Tissue Res. 2002;43(2-3): 153-160.
    OpenUrlPubMed
    1. Hu G,
    2. Vastardis H,
    3. Bendall AJ,
    4. Wang Z,
    5. Logan M,
    6. Zhang H,
    7. Nelson C,
    8. Stein S,
    9. Greenfield N,
    10. Seidman CE,
    11. Seidman JG,
    12. Abate-Shen C
    . Haploinsufficiency of MSX1: a mechanism for selective tooth agenesis. Mol Cell Biol. 1998;18(10): 6044-6051.
    OpenUrlAbstract/FREE Full Text
    1. Van den Boogaard MJ,
    2. Dorland M,
    3. Beemer FA,
    4. van Amstel HK
    . MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. Nat Genet. 2000;24(4): 342-3.
    OpenUrlCrossRefPubMedWeb of Science
    1. Peters H,
    2. Neubuser A,
    3. Kratochwil K,
    4. Balling R
    . Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998;12(17): 2735-2747.
    OpenUrlAbstract/FREE Full Text
    1. Epstein CJ,
    2. Erickson RP,
    3. Wynshaw-Boris A
    1. Patel PI,
    2. Brown DT
    . PAX9 and hypodontia. . In: Epstein CJ, Erickson RP, Wynshaw-Boris A. ., editors. Inborn errors of development. New York: Oxford University Press; 2004. 658-663.
    1. Frazier-Bowers SA,
    2. Guo DC,
    3. Cavender A,
    4. Xue L,
    5. Evans B,
    6. King T,
    7. Milewicz D,
    8. D'Souza RN
    . A novel mutation in human PAX9 causes molar oligodontia. J Dent Res. 2002;81(2): 129-133.
    OpenUrlAbstract/FREE Full Text
    1. Mostowska A,
    2. Kobielak A,
    3. Biedziak B,
    4. Trzeciak WH
    . Novel mutation in the paired box sequence of PAX9 gene in a sporadic form of oligodontia. Eur J Oral Sci. 2003;111(3): 272-6.
    OpenUrlCrossRefPubMedWeb of Science
    1. Das P,
    2. Hai M,
    3. Elcock C,
    4. Leal SM,
    5. Brown DT,
    6. Brook AH,
    7. Patel PI
    . Novel missense mutations and a 288-bp exonic insertion in PAX9 in families with autosomal dominant hypodontia. Am J Med Genet. 2003;118A(1): 35-42.
    OpenUrl
    1. Das P,
    2. Stockton DW,
    3. Bauer C,
    4. Shaffer LG,
    5. D'Souza RN,
    6. Wright T,
    7. Patel PI
    . Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia. Hum Genet. 2002;110(4): 371-6.
    OpenUrlCrossRefPubMedWeb of Science
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American Dental Hygienists Association: 79 (3)
American Dental Hygienists' Association
Vol. 79, Issue 3
Summer 2005
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Genes Underlying Familial Hypodontia: A Review and Discussion of the Role of Dental Hygienists in Future Research
Maria L Nino-Rosales, Pragna I Patel
American Dental Hygienists' Association Jun 2005, 79 (3) 10;

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Genes Underlying Familial Hypodontia: A Review and Discussion of the Role of Dental Hygienists in Future Research
Maria L Nino-Rosales, Pragna I Patel
American Dental Hygienists' Association Jun 2005, 79 (3) 10;
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Keywords

  • hypodontia
  • missing teeth
  • families
  • inheritance
  • genes

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