Endothelial cells play an obligatory role in regulating local vascular tone and maintaining
homeostasis in vascular biology. Cell metabolism, converting food to energy in organisms, is …

Diabetes, being the most widespread illness, poses a serious threat to global public health. It
seems that inflammation plays a critical role in the pathophysiology of diabetes. This review …

Clinical outcomes for doxorubicin (Dox) are limited by its cardiotoxicity but a combination of
Dox and agents with cardioprotective activities is an effective strategy to improve its …

cGMP is considered the only mediator synthesized by soluble guanylyl cyclase (sGC) in
response to nitric oxide (NO). However, purified sGC can synthesize several other cyclic …

Diabetes mellitus contributes to macro- and microvascular complications, leading to adverse
cardiovascular events. This study examined the effects of vitamin D deficiency on the …

Diabetes impairs endothelium-dependent relaxations. The present study evaluated the
contribution of different endothelium-dependent relaxing mechanisms to the regulation of …

Adenosine monophosphate‐activated protein kinase (AMPK), expressed/present ubiquitously
in the body, contributes to metabolic regulation. In the vasculature, activation of AMPK is …

Nuclear factor kappa B (NF-κB) activation contributes to many vascular inflammatory diseases.
The present study tested the hypothesis that microRNA-17-3p (miR-17-3p) suppresses …

Diabetes is associated with endothelial dysfunction, which is characterized by impaired
endothelium-dependent relaxations. The present study aimed to examine the role of nitric oxide (…

Aims Soluble guanylyl cyclase (sGC) is a heterodimer. The dimerization of the enzyme is
obligatory for its function in mediating actions caused by agents that elevate cyclic guanosine …