Aims The original Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD)
Axis I diagnostic algorithms have been demonstrated to be reliable. However, the …

In 2006, the OPPERA project (Orofacial Pain: Prospective Evaluation and Risk Assessment)
set out to identify risk factors for development of painful temporomandibular disorder (TMD). …

… In 1993, Maixner and Humphrey 160 reported sex differences in pain and cardiovascular
responses to forearm ischemia in humans. Paradoxically, the majority, if not all, pain-related …

Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function,
and affective mood. Three common haplotypes of the human COMT gene, divergent in …

Pain sensitivity varies substantially among humans. A significant part of the human population
develops chronic pain conditions that are characterized by heightened pain sensitivity. …

We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4)
synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is …

Many clinical pain conditions, including migraine, fibromyalgia, and temporomandibular
disorders, occur more frequently among females than males. Greater pain sensitivity among …

Idiopathic pain disorders 1 (IPDs) consist of such conditions as temporomandibular joint
disorders (TMJD), fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), chronic …

Chronic pain is highly variable between individuals, as is the response to analgesics.
Although much of the variability in chronic pain and analgesic response is heritable, an …

Case-control studies have consistently associated psychological factors with chronic pain in
general and with temporomandibular disorder (TMD) specifically. However, only a handful …