Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice
PJ Kuhlencordt, R Gyurko, F Han, M Scherrer-Crosbie… - Circulation, 2001 - Am Heart Assoc
Background To test whether deficiency in endothelial nitric oxide synthase (eNOS) affects
atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-…
atherosclerosis development, we compared lesion formation in apolipoprotein E (apoE)/eNOS-…
In vivo imaging of proteolytic activity in atherosclerosis
…, CH Tung, U Mahmood, V Ntziachristos, R Gyurko… - Circulation, 2002 - Am Heart Assoc
Background— Atherosclerotic plaque rupture, the most important cause of acute cardiovascular
incidents, has been strongly associated with vascular inflammation. On the basis of the …
incidents, has been strongly associated with vascular inflammation. On the basis of the …
Deletion of exon 6 of the neuronal nitric oxide synthase gene in mice results in hypogonadism and infertility
R Gyurko, S Leupen, PL Huang - Endocrinology, 2002 - academic.oup.com
Nitric oxide (NO) has been recognized as a modulator in reproductive functions, but it is not
clear whether NO is required for fertility. The first line of mice deficient in neuronal NO …
clear whether NO is required for fertility. The first line of mice deficient in neuronal NO …
Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice
R Gyurko, CC Siqueira, N Caldon, LI Gao… - The Journal of …, 2006 - journals.aai.org
The role of polymorphonuclear neutrophils (PMN) in mediating diabetic tissue damage to the
periodontium was investigated in a novel model of chronic hyperglycemia, the Akita mouse…
periodontium was investigated in a novel model of chronic hyperglycemia, the Akita mouse…
Resolvin E1 and chemokine-like receptor 1 mediate bone preservation
…, CN Serhan, TE Van Dyke, R Gyurko - The Journal of …, 2013 - journals.aai.org
The polyunsaturated ω-3 fatty acid eicosapentaenoic acid–derived resolvin E1 (RvE1)
enhances resolution of inflammation, prevents bone loss, and induces bone regeneration. …
enhances resolution of inflammation, prevents bone loss, and induces bone regeneration. …
Association between time since quitting smoking and periodontitis in former smokers in the National Health and Nutrition Examination Surveys (NHANES) 2009 to …
…, ZS Natto, JB Midle, R Gyurko… - Journal of …, 2019 - Wiley Online Library
Background The aims of this study were to analyze the periodontal conditions among non‐smokers,
former smokers and current smokers in the two National Health and Nutrition …
former smokers and current smokers in the two National Health and Nutrition …
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double …
J Chen, PJ Kuhlencordt, J Astern, R Gyurko… - Circulation, 2001 - Am Heart Assoc
Background Apolipoprotein E (apoE)/endothelial nitric oxide synthase (eNOS) double
knockout (DKO) mice demonstrate accelerated atherosclerosis and develop abdominal aortic …
knockout (DKO) mice demonstrate accelerated atherosclerosis and develop abdominal aortic …
Modulation of mouse cardiac function in vivo by eNOS and ANP
R Gyurko, P Kuhlencordt… - American Journal of …, 2000 - journals.physiology.org
To study the role of endothelial nitric oxide synthase (eNOS) in cardiac function, we compared
eNOS expression, contractility, and relaxation in the left ventricles of wild-type and eNOS-…
eNOS expression, contractility, and relaxation in the left ventricles of wild-type and eNOS-…
Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin
R Gyurko, D Wielbo, MI Phillips - Regulatory peptides, 1993 - Elsevier
To determine the role of angiotensinogen and angiotensin II type-1 (AT 1 ) receptor genes
in hypertension, spontaneously hypertensive rats (SHR) were injected with synthetic …
in hypertension, spontaneously hypertensive rats (SHR) were injected with synthetic …
iNOS‐derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature‐induced periodontitis in rats
…, SKP Costa, TE Van Dyke, R Gyurko… - Journal of …, 2011 - Wiley Online Library
Background: Inflammatory stimuli activate inducible nitric oxide synthase (iNOS) in a variety
of cell types, including osteoclasts (OC) and osteoblasts, resulting in sustained NO …
of cell types, including osteoclasts (OC) and osteoblasts, resulting in sustained NO …