Aims Treating to low disease activity is routine in rheumatoid arthritis, but no comparable
goal has been defined for systemic lupus erythematosus (SLE). We sought to define and …

Objectives. In a multi-centre study, we sought to determine whether extent of disease on
high-resolution CT (HRCT) lung, reported using a simple grading system, is predictive of decline …

Introduction The prevalence of antibodies to RNA polymerase III (anti-RNAP) differs among
systemic sclerosis (SSc) cohorts worldwide. Previously reported associations of anti-RNAP …

Objective To achieve consensus on a definition of remission in SLE (DORIS). Background
Remission is the stated goal for both patient and caregiver, but consensus on a definition of …

Objective To determine mortality and causes of death in a multinational inception cohort of
subjects with systemic sclerosis (SSc). Methods We quantified mortality as standardized …

Objective Selection of flare as the primary outcome variable in systemic lupus erythematosus
(SLE) clinical trials fails to capture patients with persistently active disease (PAD). We …

Systemic sclerosis (SSc) is a multisystem auto-immune disease. The two main subtypes of
SSc (limited and diffuse) typically have differing courses and prognoses. New classification …

… Dr Nikpour has received research grant support from Actelion, BMS, GSK, Janssen, and
UCB and honoraria from Actelion, Boehringer Ingelheim, Janssen, Eli Lilly, Pfizer, and UCB. Dr …

Background Systemic lupus erythematosus (SLE) is associated with significant impairment
of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low …

Signs and symptoms of arrhythmias or conduction defects are frequently reported in patients
with SSc. These rhythm disorders may have several origins (ie related to primary heart …