PURPOSE The purine analogs, fludarabine, cladribine, and pentostatin, are active against
a broad spectrum of indolent lymphoid malignancies. They also have similar toxicities, …

Background Stimulating an immune response against cancer with the use of vaccines remains
a challenge. We hypothesized that combining a melanoma vaccine with interleukin-2, an …

Background The incidence of anal cancer is substantially higher among persons living with
the human immunodeficiency virus (HIV) than in the general population. Similar to cervical …

BACKGROUND: Tumor shrinkage is a common end point used in screening new cytotoxic
agents. The standard World Health Organization criterion for partial response is a 50% or …

PURPOSE: The incidence of secondary leukemia after epipodophyllotoxin treatment and
the relationship between epipodophyllotoxin cumulative dose and risk are not well …

PURPOSE To provide an investigational drug, paclitaxel, now commercially available, to
women with refractory ovarian cancer and to evaluate response and toxicity in these patients. …

Gait analysis, the systematic study of human walking, is a field that has been studied for well
over 100 years. With the technological and scientific advancements of the last several …

Case reports and cohort studies have linked bisphosphonate therapy and osteonecrosis of
the jaws (ONJ), but neither causality nor specific risks for lesion development have been …

Rationale: Randomized controlled trials have been unable to detect a cardiovascular benefit
of continuous positive airway pressure in unselected patients with obstructive sleep apnea (…

PURPOSE: The nucleoside analogs fludarabine, 2′-deoxycoformycin (DCF), and 2-chlorodeoxyadenosine
(CdA), commonly used in the treatment of patients with indolent lymphoid …