[PDF][PDF] Access to oral health care: a national crisis and call for reform
CH Bersell - American Dental Hygienists' Association, 2017 - jdh.adha.org
Purpose: According to the report Healthy People 2020, oral health is integral to overall health
and access to dental services is essential to promoting and maintaining good oral health. …
and access to dental services is essential to promoting and maintaining good oral health. …
De novo KCNB1 mutations in epileptic encephalopathy
A Torkamani, K Bersell, BS Jorge… - Annals of …, 2014 - Wiley Online Library
… KCNB1 encodes the alpha subunit of the K V 2.1 voltage-gated potassium channel, a
delayed rectifier potassium channel that is an important regulator of neuronal excitability. The …
delayed rectifier potassium channel that is an important regulator of neuronal excitability. The …
Transcriptional dysregulation underlies both monogenic arrhythmia syndrome and common modifiers of cardiac repolarization
Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function
variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated …
variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated …
Azithromycin causes a novel proarrhythmic syndrome
Z Yang, JK Prinsen, KR Bersell, W Shen… - Circulation …, 2017 - Am Heart Assoc
… Although these toxic effects have not been observed during oral dosing of azithromycin, we
cannot rule out the participation of multi-ion channel block to drug-mediated sudden cardiac …
cannot rule out the participation of multi-ion channel block to drug-mediated sudden cardiac …
Anticancer drug-induced cardiac rhythm disorders: current knowledge and basic underlying mechanisms
J Alexandre, JJ Moslehi, KR Bersell… - Pharmacology & …, 2018 - Elsevier
… Ventricular arrhythmias, with a subset of them being torsades-de-pointes (TdP) favored by
QTc prolongation have been reported: this may be the result of direct hERG-channel inhibition …
QTc prolongation have been reported: this may be the result of direct hERG-channel inhibition …
Isolation and characterization of intact cardiomyocytes from frozen and fresh human myocardium and mouse hearts
H Liu, K Bersell, B Kühn - Cardiac Regeneration: Methods and Protocols, 2021 - Springer
… It is important that the bright-field channel is the current working channel; it is only in this
channel if the selected area is cut off but the immunostained pattern is preserved. …
channel if the selected area is cut off but the immunostained pattern is preserved. …
Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes
… Blebbistatin is a myosin ATPase inhibitor with minimal effects on membrane ion channel
function that reduces myofilament Ca sensitivity in skinned TnT-I79N fibers to that of wild-type …
function that reduces myofilament Ca sensitivity in skinned TnT-I79N fibers to that of wild-type …
[PDF][PDF] Epilepsy-Associated Point Mutation in the Pore Domain of Kv2. 1
KR Bersell, BS Jorge, JA Kearney, AL George - Biophysical Journal, 2014 - cell.com
… + channel expression of activated microglia in adult brain. … Channel expression was
significantly higher than on … blockade of one microglial K + channel is sufficient to improve …
significantly higher than on … blockade of one microglial K + channel is sufficient to improve …
Contrasting Nav1.8 Activity in Scn10a−/− Ventricular Myocytes and the Intact Heart
… Taken together, the expression data, the in vitro differences, and the lack of in vivo effects
suggest that the channel is expressed, but at levels below the limits of our detection, in …
suggest that the channel is expressed, but at levels below the limits of our detection, in …
A Common Genetic Variant of the Cardiac Sodium Channel Predisposes to Drug-induced QT Prolongation
Background and Aim: Gain-of-function (GOF) variants in the cardiac voltage-gated sodium-channel
(SCN5A) can cause type 3 Long QT syndrome (LQTS), which can lead to sudden …
(SCN5A) can cause type 3 Long QT syndrome (LQTS), which can lead to sudden …