Local minocycline effect on inflammation and clinical attachment during periodontal maintenance: randomized clinical trial

AC Killeen, JA Harn, LM Erickson, F Yu… - Journal of …, 2016 - Wiley Online Library
Background: Minocycline microspheres (MMs) are being used to treat residual inflamed
periodontal pockets during periodontal maintenance therapy (PMT), but evidence for efficacy …

Local simvastatin and inflammation during periodontal mini‐flap wound healing: Exploratory results

DL Christiansen, AC Killeen… - Journal of …, 2023 - Wiley Online Library
Background The objective of this exploratory study was to evaluate inflammatory markers in
periodontal maintenance patients from a randomized, double‐masked, parallel intervention …

Impact of local and systemic alendronate on simvastatin‐induced new bone around periodontal defects

AC Killeen, PA Rakes, MJ Schmid… - Journal of …, 2012 - Wiley Online Library
Background: Simvastatin has been shown to stimulate new bone growth on rat mandibles,
but much of the bone is lost over time. The purpose of this study is to evaluate the impact of a …

Do mobility and occlusal trauma impact periodontal longevity?

RA Reinhardt, AC Killeen - Dental Clinics, 2015 - dental.theclinics.com
Increasing mobility during periodontal maintenance therapy is a concern, because it may
indicate increased deterioration of the periodontium. This may be a result of increasing size of …

Simvastatin application to augment facial jaw bone in a dog model: pilot study

…, JM Chamberlain, M Byarlay, AC Killeen… - Journal of …, 2011 - Wiley Online Library
Background: Locally injected simvastatin (SIM) has been shown to induce bone growth in rat
models. The purpose of this study is to evaluate the effects of locally injected simvastatin in …

Two-year randomized clinical trial of adjunctive minocycline microspheres in periodontal maintenance

AC Killeen, JA Harn, J Jensen, F Yu, S Custer… - American Dental …, 2018 - jdh.adha.org
Purpose: The purpose of this study was to evaluate the effects of repeated scaling and root
planing (SRP), with or without locally-delivered minocycline microspheres (MM) on residual …

Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: A randomized clinical trial

AC Killeen, LE Krell, M Bertels… - Journal of …, 2022 - Wiley Online Library
Background The purpose of this double‐masked, randomized, controlled trial was to determine
if the local application of simvastatin (SIM), combined with minimally invasive papilla …

The Development of Thermoresponsive Polymeric Simvastatin Prodrug for the Treatment of Experimental Periodontitis in Rats

…, S Arash, RA Reinhardt, AC Killeen… - Molecular …, 2023 - ACS Publications
Periodontitis (PD) is a severe inflammatory gum pathology that damages the periodontal soft
tissue and bone. It is highly prevalent in the US, affecting more than 47% of adults. Besides …

Impact of modifiable risk factors on bone loss during periodontal maintenance

X Cui, E Monacelli, AC Killeen, K Samson… - Operative …, 2019 - meridian.allenpress.com
Objectives: The aim of this study was to analyze modifiable patient risk factors from dental
chart histories and radiographs for progressive mild-moderate periodontitis during periodontal …

Effects of enamel matrix derivative on clinical and inflammatory outcomes in periodontal maintenance patients: randomized controlled clinical trial

…, RA Reinhardt, JB Payne, AC Killeen - Journal of …, 2020 - Wiley Online Library
Background Efficient methods to treat persistent pockets during periodontal maintenance
therapy (PMT) require further investigation. The hypothesis of this randomized controlled …