Becoming a phenotypic male is ultimately determined by androgen-induced masculinization.
Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, …

Testosterone is essential for maintaining spermatogenesis and male fertility. However, the
molecular mechanisms by which testosterone acts have not begun to be revealed until …

Androgens are essential for normal spermatogenesis and male fertility, but how androgens
exert this effect remains uncertain. Androgen receptors (ARs) are expressed in several …

Androgens such as testosterone are steroid hormones essential for normal male reproductive
development and function. Mutations of androgen receptors (AR) are often found in …

Fetal growth plays a role in programming of adult cardiometabolic disorders, which in men,
are associated with lowered testosterone levels. Fetal growth and fetal androgen exposure …

The Sertoli cells are critical regulators of testis differentiation and development. In the adult,
however, their known function is restricted largely to maintenance of spermatogenesis. To …

The gonad is a unique biological system for studying cell-fate decisions. However, major
questions remain regarding the identity of somatic progenitor cells and the transcriptional …

Sertoli cells (SCs) regulate testicular fate in the differentiating gonad and are the main regulators
of spermatogenesis in the adult testis; however, their role during the intervening period …

Sertoli cells regulate differentiation and development of the testis and are essential for
maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during …

Testosterone deficiency is epidemic in obese ageing males with type 2 diabetes, but the
direction of causality remains unclear. Testosterone-deficient males and global androgen …