Abstract
The inhibition of bacterial attachment to the tooth surface is one possible approach to plaque control. This study evaluated in vivo the plaque inhibitory action of a novel copolymer reported to have considerable antiadhesive properties in vitro. The study was a single blind, 5-treatment, randomised Latin square crossover design, incorporating balance for carry-over effects. The rinses were the antiadhesive (1%), the antiadhesive with 0.02% chlorhexidine, a 0.2% chlorhexidine rinse product, an essential oil/phenolic rinse product and water. 15 volunteers participated and on day 1 of each study period were rendered plaque-free, ceased toothcleaning and rinsed 2 x daily, under supervision, with the allocated formulation. On day 5, plaque was scored by index and area. Washout periods were 2 1/2 days. Alone or combined with chlorhexidine, the antiadhesive agent showed no effects greater than water. The chlorhexidine rinse was significantly more effective than the essential oil/phenolic rinse which in turn was significantly more effective than the other rinses.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Anti-Infective Agents, Local / administration & dosage
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Anti-Infective Agents, Local / therapeutic use*
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Bacterial Adhesion / drug effects
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Chlorhexidine / administration & dosage
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Chlorhexidine / analogs & derivatives
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Chlorhexidine / therapeutic use*
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Cross-Over Studies
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Dental Plaque / microbiology
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Dental Plaque / physiopathology
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Dental Plaque / prevention & control*
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Dental Plaque Index
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Dental Prophylaxis
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Humans
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Male
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Mouthwashes*
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Oils, Volatile / administration & dosage
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Oils, Volatile / therapeutic use
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Oral Hygiene
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Phenols / administration & dosage
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Phenols / therapeutic use*
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Polyethylene Glycols / administration & dosage
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Polyethylene Glycols / therapeutic use
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Polymethacrylic Acids / administration & dosage
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Polymethacrylic Acids / therapeutic use
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Single-Blind Method
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Surface-Active Agents / administration & dosage
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Surface-Active Agents / therapeutic use*
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Water
Substances
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Anti-Infective Agents, Local
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M 239144
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Mouthwashes
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Oils, Volatile
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Phenols
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Polymethacrylic Acids
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Surface-Active Agents
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Water
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Polyethylene Glycols
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chlorhexidine gluconate
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Chlorhexidine