Humans, like every other living thing on Earth, have evolved in a world dominated by many billions of microscopic life forms. Most of the time, we live in a state of harmony (or even mutualism) with our invisible coinhabitants. When this balance becomes disturbed however, the consequences can be devastating. Infectious diseases including malaria, tuberculosis, and AIDS remain the world's greatest mass murderers. Dental workers strive to reduce infection risks for their patients through infection control measures that reduce or eliminate potentially pathogenic agents in the clinical environment. As increasing numbers of patients with varying degrees of immune suppression present for dental treatment, the need to ensure an aseptic treatment environment will become a higher priority for the dental profession. The possibility that exposure to aerosols contaminated with endotoxin might exacerbate asthma or cause chronic respiratory problems in dental health care workers should be investigated. Although direct evidence of widespread complications among patients or occupationally acquired illness among dental workers is presently lacking, reducing the numbers of microorganisms present in dental treatment water is consistent with other empiric measures that form the basis of infection-control practice.