Case reportOsteonecrosis of the Jaw in a Patient on Denosumab
Section snippets
Report of a Case
A 65-year-old woman presented to the oral and maxillofacial surgery clinic at the University of California, Los Angeles (UCLA) School of Dentistry with pain and exposed bone in the posterior mandible of unknown duration. Her medical history was significant for non–insulin-dependent diabetes mellitus, morbid obesity, a below-the-knee amputation for congenitally missing right fibula, hypertension, congestive heart failure, hyperlipidemia hypothyroidism, and a sacral giant cell tumor (GCT). Her
Discussion
ONJ is a complicated disease most commonly associated with BP treatment. Here we report development of ONJ in a patient on Denosumab therapy for the management of a GCT. Although this patient was medically compromised and on multiple medications, a common thread in ONJ development may be inhibition of osteoclastic activity, mediated in this case by Denosumab.
Osteoclasts are derived from the hematopoietic stem cell lineage and depend on other cells, such as marrow stromal cells and osteoblasts,
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This work was supported by NIH/NIDCRDE019465 grant.