PT  - JOURNAL ARTICLE
AU  - Talbert, Jennifer
AU  - Elter, John
AU  - Jared, Heather L
AU  - Offenbacher, Steve
AU  - Southerland, Janet
AU  - Wilder, Rebecca S
TI  - The Effect of Periodontal Therapy on TNF-α, IL-6 and Metabolic Control in Type 2 Diabetics
DP  - 2006 Apr 01
TA  - American Dental Hygienists Association
PG  - 7--7
VI  - 80
IP  - 2
4099  - http://jdh.adha.org/content/80/2/7.short
4100  - http://jdh.adha.org/content/80/2/7.full
SO  - J Dent Hyg2006 Apr 01; 80
AB  - Purpose. This pilot study investigated if scaling and root planing (S&RP) was an effective intervention in reducing levels of inflammatory markers TNF-α and IL-6 in a type 2 diabetic population Methods. Twenty-five patients with type 2 diabetes, 18-64 years of age were enrolled having 4 or more sites with pocket depths ≥ 5mm and 2 or more sites with attachment loss ≥ 3mm. Participants received S&RP following collection of gingival crevicular fluid and serum which were analyzed for TNF-α and IL-6. After 3 months post-treatment levels were collected. Serum pre-and post-treatment levels were analyzed using a paired t test at a significance level of p≤0.05. Mean TNF-α was 1.7pg/ml at baseline and post-treatment was 4.0pg/ml. Mean IL-6 was 2.8pg/ml at baseline and post-treatment 6.0pg/ml. Results. Both mean TNF-α and IL-6 were increased following S&RP ; however, the observed increases were not statistically significant. While participants improved on periodontal measures following therapy, systemic measures of inflammation (TNF-α and IL-6) did not show the hypothesized reductions. Conclusion. Further studies are needed to determine effectiveness of S&RP on inflammatory mediators in a population with type 2 diabetes.