RT Journal Article SR Electronic T1 Proliferative verrucous leukoplakia: An aggressive form of oral leukoplakia JF American Dental Hygienists Association JO J Dent Hyg FD American Dental Hygienists Association SP 7 OP 7 VO 78 IS 3 A1 Thomas P Shopper A1 Robert B Brannon A1 William H Stalker YR 2004 UL http://jdh.adha.org/content/78/3/7.abstract AB Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia that is persistent, often multifocal, and refractory to treatment with a high risk of recurrence and malignant transformation. This article describes the clinical aspects and histologic features of a case that demonstrated the typical behavior pattern in a long-standing, persistent lesion of PVL of the mandibular gingiva and that ultimately developed into squamous cell carcinoma. Prognosis is poor for this seemingly harmless-appearing white lesion of the oral mucosa.