%0 Journal Article %A Thomas P Shopper %A Robert B Brannon %A William H Stalker %T Proliferative verrucous leukoplakia: An aggressive form of oral leukoplakia %D 2004 %J American Dental Hygienists Association %P 7-7 %V 78 %N 3 %X Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia that is persistent, often multifocal, and refractory to treatment with a high risk of recurrence and malignant transformation. This article describes the clinical aspects and histologic features of a case that demonstrated the typical behavior pattern in a long-standing, persistent lesion of PVL of the mandibular gingiva and that ultimately developed into squamous cell carcinoma. Prognosis is poor for this seemingly harmless-appearing white lesion of the oral mucosa. %U https://jdh.adha.org/content/jdenthyg/78/3/7.full.pdf