Skip to main content

Main menu

  • Home
  • Articles
    • Current Issue
    • Archived Issues
  • Info for
    • Authors
    • Advertisements
    • Subscribing
  • About
    • About Us
    • Editorial Board
    • JDH Reviewers
  • More
    • Alerts
    • Feedback
    • Permissions
    • Accessibility Statement

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
Journal of Dental Hygiene

Visit the American Dental Hygienists' Association's main website

  • Register
  • Subscribe
  • My alerts
  • Log in
Journal of Dental Hygiene

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Archived Issues
  • Info for
    • Authors
    • Advertisements
    • Subscribing
  • About
    • About Us
    • Editorial Board
    • JDH Reviewers
  • More
    • Alerts
    • Feedback
    • Permissions
    • Accessibility Statement
  • Visit jdenthyg on Facebook
  • Follow jdenthyg on Twitter
  • Follow jdenthyg on Instagram
  • Follow jdenthyg on Linkedin
  • RSS feeds
Research ArticleShort Report
Open Access

Stannous Fluoride Toothpaste: Improving gingival health without a new habit adoption

Beth A. Jordan and Adam E. Saltz
American Dental Hygienists' Association August 2026, 100 (4) 68-74;
Beth A. Jordan
The Procter & Gamble Company, Mason, OH, USA
RDH, MS, FADHA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: jordan.ba.1{at}pg.com
Adam E. Saltz
Private practice clinician, South Portland, ME, USA
DMD, MS, MPH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Loe H,
    2. Theilade E,
    3. Jensen SB.
    Experimental gingivitis in man. J Periodontol (1930). 1965 May-Jun; 36:177–87.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. Khan SA,
    2. Kong EF,
    3. Meiller TF, et al.
    Periodontal diseases: Bug induced, host promoted. PLoS Pathog. 2015 Jul 30; 11(7):e1004952.
    OpenUrlCrossRefPubMed
  3. 3.
    1. Benzian H,
    2. Williams D.
    editors. The challenge of oral disease-A call for global action. The Oral Health Atlas. 2nd ed. FDI World Dental Federation. Geneva; 2015. 22p.
  4. 4.↵
    1. Baima G,
    2. Arce M,
    3. Romandini M, et al.
    Inflammatory and immunological basis of periodontal diseases. J Periodontal Res. 2025 Oct 9; 1-34.
  5. 5.↵
    1. Huang S,
    2. He T,
    3. Yue F, et al.
    Longitudinal multi-omics and microbiome meta-analysis identify an asymptomatic gingival state that links gingivitis, periodontitis, and aging. mBio. 2021 Mar 9; 12(2):e03281-20.
    OpenUrlPubMed
  6. 6.↵
    1. Wu L,
    2. Huang CM,
    3. Wang Q, et al.
    Burden of severe periodontitis: new insights based on a systematic analysis from the Global Burden of Disease Study 2021. BMC Oral Health. 2025 May 31;25(1):861.
    OpenUrlPubMed
  7. 7.↵
    1. Perić M,
    2. Marhl U,
    3. Gennai S, et al.
    Treatment of gingivitis is associated with reduction of systemic inflammation and improvement of oral health-related quality of life: A randomized clinical trial. J Clin Periodontol. 2022 49(9):899–910.
    OpenUrlPubMed
  8. 8.↵
    1. American Dental Hygienists’ Association
    . Standards for clinical dental hygiene practice [Internet]. Chicago (IL): American Dental Hygienists’ Association; 2025 Mar 20 [cited 2026 Apr 15]. Available from: https://www.adha.org/resources/standards/
  9. 9.↵
    1. Slot DE,
    2. Wiggelinkhuizen L,
    3. Rosema NA, et al.
    The efficacy of manual toothbrushes following a brushing exercise: A systematic review. Int J Dent Hyg. 2012 Aug;10(3):187-97.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Deinzer R,
    2. Ebel S,
    3. Blättermann H, et al.
    Toothbrushing: to the best of one’s abilities is possibly not good enough. BMC Oral Health. 2018 Oct 19;18(1):167.
    OpenUrlPubMed
  11. 11.↵
    1. Figuero E,
    2. Roldán S,
    3. Serrano J, et al.
    Efficacy of adjunctive therapies in patients with gingival inflammation: A systematic review and meta-analysis. J Clin Periodontol. 2020 Jul;47 Suppl 22:125-143.
    OpenUrlPubMed
  12. 12.↵
    1. Biesbrock A,
    2. He T,
    3. DiGennaro J, et al.
    The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta-analysis of eighteen randomized controlled trials. J Clin Periodontol. 2019 Dec; 46(12):1205-16.
    OpenUrlPubMed
  13. 13.↵
    1. FDA
    . Anti-caries drug products for over-the-counter human use; final monograph [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2023 [cited 2026 Apr 14]. Available from: https://www.ecfr.gov/current/title-21/chapter-I/subchapter-D/part-355
  14. 14.↵
    1. IFDH
    . 2019 toothpaste survey [Internet]. Rockville (MD): International Federation of Dental Hygienists; 2019 [cited 2026 Apr 2]. Available from: https://ifdh.org/ifdh-2019-toothpaste-survey/
  15. 15.↵
    1. He T,
    2. Nachnani S,
    3. Lee S, et al.
    The relative clinical efficacy of three 0.454% stannous fluoride dentifrices for the treatment of gingivitis over 3 months. Am J Dent. 2020 Aug; 33(4):218-24.
    OpenUrlPubMed
  16. 16.↵
    1. He T,
    2. Grender J,
    3. Zou Y, et al.
    A 3-month randomized trial evaluating the effects of stannous fluoride bioavailability on gingivitis. Am J Dent. 2025 Jun; 38(3):155-60.
    OpenUrlPubMed
  17. 17.↵
    1. Valkenburg C,
    2. Van der Weijden FA,
    3. Slot DE.
    Plaque control and reduction of gingivitis: the evidence for dentifrices. Periodontol 2000. 2019 Feb; 79(1):221-32.
    OpenUrl
  18. 18.↵
    1. Johannsen A,
    2. Emilson CG,
    3. Johannsen G, et al.
    Effects of stabilized stannous fluoride dentifrice on dental calculus, dental plaque, gingivitis, halitosis and stain: A systematic review. Heliyon. 2019 Dec 9; 5(12):e02850.
    OpenUrl
  19. 19.↵
    1. Konradsson K,
    2. Lingström P,
    3. Emilson CG, et al.
    Stabilized stannous fluoride dentifrice in relation to dental caries, dental erosion and dentin hypersensitivity: a systematic review. Am J Dent. 2020 Apr; 33(2):95-105.
    OpenUrlPubMed
  20. 20.↵
    1. West NX,
    2. He T,
    3. Zou Y, et al.
    Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: effects on dentine hypersensitivity and enamel erosion. J Dent. 2021 Feb; 105:103566.
    OpenUrlPubMed
  21. 21.↵
    1. He T,
    2. Zou Y,
    3. DiGennaro J,
    4. Biesbrock AR.
    Novel findings on anti-plaque effects of stannous fluoride. Am J Dent. 2022 Dec; 35(6):297–307.
    OpenUrlPubMed
  22. 22.↵
    1. Cannon M,
    2. Khambe D,
    3. Klukowska M, et al.
    Clinical effects of stabilized stannous fluoride dentifrice in reducing plaque microbial virulence II: metabonomic changes. J Clin Dent. 2018 Mar; 29(1):1-12.
    OpenUrlPubMed
  23. 23.↵
    1. Ramji N,
    2. Xie S,
    3. Bunger A, et al.
    Effects of stannous fluoride dentifrice on gingival health and oxidative stress markers: a prospective clinical trial. BMC Oral Health. 2024 Aug 30; 24(1):1019.
    OpenUrlPubMed
  24. 24.↵
    1. Haught C,
    2. Xie S,
    3. Circello B, et al.
    Lipopolysaccharide and lipoteichoic acid virulence deactivation by stannous fluoride. J Clin Dent. 2016 Sep; 27(3):84-9.
    OpenUrlPubMed
  25. 25.↵
    1. Xie S,
    2. Haught JC,
    3. Tansky CS, et al.
    Clinical effects of stannous fluoride dentifrice in reducing plaque microbial virulence III: Lipopolysaccharide and TLR2 reporter cell gene activation. Am J Dent. 2018 Aug;31(4):215-224.
    OpenUrlPubMed
  26. 26.↵
    1. Chapple ILC,
    2. Mealey BL,
    3. Van Dyke TE, et al.
    Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89(Suppl 1):S74–S84.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Schätzle M,
    2. Löe H,
    3. Bürgin W, et al.
    Clinical course of chronic periodontitis. I. Role of gingivitis. J Clin Periodontol. 2003 Oct;30(10):887-901. Erratum in: J Clin Periodontol. 2004 Sep;31(9):813.
    OpenUrlCrossRefPubMedWeb of Science
  28. 28.↵
    1. Clark-Perry D,
    2. Levin L.
    Comparison of new formulas of stannous fluoride toothpastes with other commercially available fluoridated toothpastes: A systematic review and meta-analysis of randomised controlled trials. Int Dent J. 2020 Dec; 70(6):418-26.
    OpenUrlPubMed
  29. 29.
    1. Gunsolley JC.
    A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc. 2006 Dec; 137(12):1649-57.
    OpenUrlAbstract/FREE Full Text
  30. 30.↵
    1. Paraskevas S,
    2. van der Weijden GA.
    A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol. 2006 Jan; 33(1):1-13.
    OpenUrlPubMed
  31. 31.↵
    1. He T,
    2. Grender J,
    3. Farrell S,
    4. Biesbrock AR.
    Relationship between 1-, 3-, and 6-month gingival bleeding outcomes. JDR Clin Trans Res. 2024 Jul; 9(3):286-93.
    OpenUrlPubMed
  32. 32.↵
    1. Hu P,
    2. Xie S,
    3. Shi B, et al.
    The effect of oral care product ingredients on oral pathogenic bacteria transcriptomics through RNA-Seq. Microorganisms. 2024 Dec 23; 12(12):2668.
    OpenUrlPubMed
  33. 33.↵
    1. Xie S,
    2. Iberi V,
    3. Boissy Y, et al.
    Stannous fluoride forms aggregates between outer and inner membranes leading to membrane rupture of Porphyromonas gingivalis and Prevotella pallens. Front Oral Health. 2024 Jun 26; 5:1427008.
    OpenUrlPubMed
  34. 34.↵
    1. Chen D,
    2. Chew D,
    3. Xiang Q, et al.
    Interactions and effects of a stannous-containing sodium fluoride dentifrice on oral pathogens and the oral microbiome. Front Microbiol. 2024 Feb 15; 15:1327913.
    OpenUrlPubMed
  35. 35.↵
    1. Kruse AB,
    2. Schlueter N,
    3. Kortmann VK, et al.
    Long-term use of oral hygiene products containing stannous and fluoride ions: Effect on viable salivary bacteria. Antibiotics (Basel). 2021 Apr 22;10(5):481.
    OpenUrlPubMed
  36. 36.↵
    1. Netea MG,
    2. Balkwill F,
    3. Chonchol M, et al.
    A guiding map for inflammation. Nat Immunol. 2017 Jul 19;18(8):826-31.
    OpenUrlCrossRefPubMed
  37. 37.
    1. Takeuchi O,
    2. Akira S.
    Pattern recognition receptors and inflammation. Cell. 2010 Mar 19; 140(6):805–20.
    OpenUrlCrossRefPubMedWeb of Science
  38. 38.↵
    1. Chen L,
    2. Deng H,
    3. Cui H, et al.
    Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14; 9(6):7204-18.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Turner MD,
    2. Nedjai B,
    3. Hurst T, et al.
    Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta. 2014 Nov; 1843(11):2563-82.
    OpenUrlCrossRefPubMed
  40. 40.↵
    1. Fullerton JN,
    2. Gilroy DW.
    Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov. 2016 Aug; 15(8):551-67.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Klukowska M,
    2. Haught JC,
    3. Xie S, et al.
    Clinical effects of stabilized stannous fluoride dentifrice in reducing plaque microbial virulence I: Microbiological and receptor cell findings. J Clin Dent. 2017 Jun; 28(2):16-26.
    OpenUrlPubMed
  42. 42.↵
    1. Charpentier LA,
    2. Dolben EF,
    3. Hendricks MR, et al.
    Bacterial outer membrane vesicles and immune modulation of the host. Membranes (Basel). 2023 Aug 24; 13(9):752.
    OpenUrlCrossRefPubMed
  43. 43.
    1. Zhang Z,
    2. Liu D,
    3. Liu S, et al.
    The role of Porphyromonas gingivalis outer membrane vesicles in periodontal disease and related systemic diseases. Front Cell Infect Microbiol. 2021 Jan 28; 10:585917.
    OpenUrlPubMed
  44. 44.↵
    1. Xie S,
    2. Tansky CS,
    3. Ashe J, et al.
    Stannous fluoride protects gingival keratinocytes against infection and oxidative stress by Porphyromonas gingivalis outer membrane vesicles. Front Dent Med. 2024 Nov 19; 5:1492369.
    OpenUrlPubMed
  45. 45.↵
    1. Elani HW,
    2. Starr JR,
    3. Da Silva JD,
    4. Gallucci GO.
    Trends in dental implant use in the U.S., 1999-2016, and projections to 2026. J Dent Res. 2018 Dec;97(13):1424-30.
    OpenUrlCrossRefPubMed
  46. 46.↵
    1. Rokaya D,
    2. Srimaneepong V,
    3. Wisitrasameewon W, et al.
    , Peri-implantitis update: Risk indicators, diagnosis, and treatment. Eur J Dent. 2020 Oct;14(4):672-82.
    OpenUrlCrossRefPubMed
  47. 47.↵
    1. Galarraga-Vinueza ME,
    2. Pagni S,
    3. Finkelman M, et al.
    Prevalence, incidence, systemic, behavioral, and patient-related risk factors and indicators for peri-implant diseases: An AO/AAP systematic review and meta-analysis. J Periodontol. 2025;96:587–633.
    OpenUrlPubMed
  48. 48.↵
    1. Klukowska M,
    2. Ramji N,
    3. Muñoz Bodnar A, et al.
    Clinical effects of stannous fluoride dentifrice on peri-implant mucositis, plaque microbiome, and oxidative stress. Am J Dent. 2025 Apr; 38(2):59-66.
    OpenUrlPubMed
  49. 49.↵
    1. Suszcynsky-Meister E,
    2. Shauchuk A,
    3. Hare T, et al.
    Chemical effects of stannous and sodium fluoride dental treatments on titanium alloy surfaces. In: Dental materials: metal-based materials and other materials. 2018 AADR/CADR Annual Meeting; 2018 Mar 23; Fort Lauderdale (FL). [Internet]: c2026 [cited 2026 Apr 2]. Available from: https://iadr.abstractarchives.com/abstract/47am-2855013/chemical-effects-of-stannous-and-sodium-fluoride-dental-treatments-on-titanium-alloy-surfaces
  50. 50.↵
    1. Schiff T,
    2. Saletta L,
    3. Baker RA, et al.
    Anticalculus efficacy and safety of a stabilized stannous fluoride/sodium hexametaphosphate dentifrice. Compend Contin Educ Dent. 2005 Sep;26(9 Suppl 1):29-34.
    OpenUrlPubMed
  51. 51.
    1. Baig A,
    2. He T,
    3. Buisson J, et al.
    Extrinsic whitening effects of sodium hexametaphosphate--a review including a dentifrice with stabilized stannous fluoride. Compend Contin Educ Dent. 2005 Sep;26(9 Suppl 1):47-53.
    OpenUrlPubMed
  52. 52.↵
    1. Sensabaugh C,
    2. Sagel ME.
    Stannous fluoride dentifrice with sodium hexametaphosphate: Review of laboratory, clinical and practice-based data. J Dent Hyg. 2009 Spring;83(2):70-8. Epub 2009 Apr 1.
    OpenUrlFREE Full Text
  53. 53.↵
    1. Biesbrock AR,
    2. He T,
    3. Zou Y, et al.
    Randomized clinical trial evaluating kinetic benefits of desensitizing agents: Magnitude, onset, and stability of relief. J Periodontol. 2025 Dec;96(12):1339-1351.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

American Dental Hygienists' Association
Vol. 100, Issue 4
August 2026
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Dental Hygiene.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Stannous Fluoride Toothpaste: Improving gingival health without a new habit adoption
(Your Name) has sent you a message from Journal of Dental Hygiene
(Your Name) thought you would like to see the Journal of Dental Hygiene web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Stannous Fluoride Toothpaste: Improving gingival health without a new habit adoption
Beth A. Jordan, Adam E. Saltz
American Dental Hygienists' Association Aug 2026, 100 (4) 68-74;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Stannous Fluoride Toothpaste: Improving gingival health without a new habit adoption
Beth A. Jordan, Adam E. Saltz
American Dental Hygienists' Association Aug 2026, 100 (4) 68-74;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Abstract
    • INTRODUCTION
    • CONCLUSION
    • ACKNOWLEDGEMENTS
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Similar Articles

More in this TOC Section

  • Biological Dental Hygiene: Principles, educational pathways, and clinical practice considerations
  • Opportunities and Challenges of Mentoring and Developing Student Reading Comprehension, Writing, and Research Synthesis at the Undergraduate Level
Show more Short Report

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Keywords

  • stannous fluoride
  • oral hygiene
  • toothpaste
  • anti-gingivitis
  • periodontal disease
  • dental implants
  • prevention
  • dentinal hypersensitivity

About

  • About ADHA
  • About JDH
  • JDH Reviewers
  • Contact Us

Helpful Links

  • Submit a Paper
  • Author Guidelines
  • Permissions
  • FAQs

More Information

  • Advertise
  • Subscribe
  • Email Alerts
  • Help

ISSN #: 1553-0205

Copyright © 2026 American Dental Hygienists’ Association

Powered by HighWire