Purpose : While surgery remains the gold standard of therapy to correct the acquired curvature
of Peyronie’s disease, the search for a less invasive therapy continues. Transdermal drug …

Aberrant alternative splicing of mRNAs results in dysregulated gene expression in multiple
neurological disorders. Here, we show that hundreds of mRNAs are incorrectly expressed …

CD1 molecules function to present lipid-based antigens to T cells. Here we present the
crystal structure of CD1c at 2.5 Å resolution, in complex with the pathogenic Mycobacterium …

The ketonization of various renewable biomass-derived oxygenated feedstocks such as
carboxylic acids, aldehydes, alcohols, and esters is presented. As most previous ketonization …

Numerous noncoding transcripts of unknown function have recently been identified. In this
study, we report a novel mechanism that relies on transcription of noncoding RNA prt (pho1-…

Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS).
FMRP binds brain mRNAs and inhibits polypeptide elongation. Using ribosome profiling of …

In eukaryotic cells, inefficient splicing is surprisingly common and leads to the degradation
of transcripts with retained introns. How pre-mRNAs are committed to nuclear decay is …

Curry leaf (Murraya koenegii) is a common flavouring agent in Indian foods. This study
characterised the flavonol profile of curry leaf extracted with different solvents and the relative …

Background COVID-19 infection is associated with D-dimer elevations, high rates of thrombus
formation, and poor clinical outcomes. We sought to determine if empiric therapeutic …

Highly stable gold nanoparticles immobilized on the surface of amine-functionalized
nanocomposite microspheres possessing a magnetite (Fe 3 O 4 ) nanoparticle core and a silica (…