Background Epigenetic mechanisms, including methylation, can contribute to childhood
asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease …

Epigenome-wide studies of methylation in children support a role for epigenetic mechanisms
in asthma; however, studies in adults are rare and few have examined non-atopic asthma. …

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy
exposure and in adults from personal smoking. Whether a unique methylation signature …

Rationale: Methylation integrates factors present at birth and modifiable across the lifespan
that can influence pulmonary function. Studies are limited in scope and replication. Objectives…

Aim: To identify differential methylation related to prescribed opioid use. Methods: This
study examined whether blood DNA methylation, measured using Illumina arrays, differs by …

Background Transcription factors are known to play key roles in carcinogenesis and
therefore, are gaining popularity as potential therapeutic targets in drug development. A ‘master …

The objective of this study was to assess the association of exposure to metal mixtures with
semen quality and sperm DNA integrity of coke oven workers (n = 96). Urinary six metals (…

Objective This study aimed to determine (i) associations between levels of the polycyclic
aromatic hydrocarbon (PAH) mixture with 16 targeted PAH compounds in the personal …

Lung function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry GWAS meta-analysis of lung function to date, …

The objective of this study was to assess relationships between exposure to PAHs at
occupational levels and outcomes of human semen quality and sperm DNA integrity. Personal …