The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic
Alzheimer's disease (AD) is unknown. A history of stroke was found to be associated with …

The multinationalization of corporate investment in recent years has given rise to a number
of international tax avoidance schemes that may be eroding tax revenues in industrialized …

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD)
and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs in …

Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

Appraisal of the present and future impact of climate change and climate variability on the
transmission of infectious diseases is a complex but pressing public health issue. We …

Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD).
Amyloid β-protein (Aβ), the central component of neuritic plaques, is derived from β-…

The advent of deep learning has brought great change to the community of computer science
and also revitalized numerous fields where traditional machine learning methods failed to …

We have developed a fast and accurate method to engineer the Bacillus subtilis genome that
involves fusing by PCR two flanking homology regions with an antibiotic resistance gene …

The synaptic weight modification depends not only on interval of the pre‐/postspike pairs
according to spike‐timing dependent plasticity (classical pair‐STDP), but also on the timing of …

Proteolytic processing of the β-amyloid precursor protein (APP) at the β site is essential to
generate Aβ. BACE1, the major β-secretase involved in cleaving APP, has been identified as a …