Antimicrobials are valuable therapeutics whose efficacy is seriously compromised by the
emergence and spread of antimicrobial resistance. The provision of antibiotics to food animals …

The optimism of the early period of antimicrobial discovery has been tempered by the
emergence of bacterial strains with resistance to these therapeutics. Today, clinically important …

Purpose To evaluate the efficacy, safety, and pharmacokinetics of multiple doses of CCI-779,
a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced …

A ntibiotic resistance, reported for sulfonamides in the mid-1930s and for penicillins in the
1940s, remains a stubborn quandary. What was once confined mainly to hospitals …

Purpose: Patients with advanced cancer received temsirolimus (Torisel, CCI-779), a novel
inhibitor of mammalian target of rapamycin, iv once daily for 5 days every 2 weeks to …

Objectives We report the largest clinical experience using tigecycline-containing regimens for
salvage treatment of patients with Mycobacterium abscessus and Mycobacterium chelonae…

Expression profiling has demonstrated that transcriptomes of primary malignancies differ
from those in normal tissue. It is unknown, however, whether there exist “surrogate” …

The spread of wild-type Escherichia coli bearing a transferable plasmid was studied in a
farm environment. E. coli of bovine and porcine origin were marked by resistance to nalidixic …

Purpose: Given their accessibility, surrogate tissues, such as peripheral blood mononuclear
cells (PBMC), may provide potential predictive biomarkers in clinical pharmacogenomic …

Within Nepal, geographic, social, and economic barriers greatly limit access to allopathic
health care. The country therefore offered the opportunity to evaluate the effect of antibiotic …