User profiles for M. A. Ghannoum

Mahmoud Ghannoum

Case Western Reserve University
Verified email at case.edu
Cited by 45355

Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance

MA Ghannoum, LB Rice - Clinical microbiology reviews, 1999 - Am Soc Microbiol
The increased use of antibacterial and antifungal agents in recent years has resulted in the
development of resistance to these drugs. The significant clinical implication of resistance …

Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole …

…, A Espinel-Ingroff, MA Ghannoum… - Clinical Infectious …, 1997 - academic.oup.com
The availability of reproducible antifungal susceptibility testing methods now permits analysis
of data correlating susceptibility in vitro with outcome in vivo in order to define interpretive …

Potential role of phospholipases in virulence and fungal pathogenesis

MA Ghannoum - Clinical microbiology reviews, 2000 - Am Soc Microbiol
Microbial pathogens use a number of genetic strategies to invade the host and cause infection.
These common themes are found throughout microbial systems. Secretion of enzymes, …

Biofilm Formation by the Fungal PathogenCandida albicans: Development, Architecture, and Drug Resistance

…, LL Hoyer, T McCormick, MA Ghannoum - Journal of …, 2001 - Am Soc Microbiol
Biofilms are a protected niche for microorganisms, where they are safe from antibiotic
treatment and can create a source of persistent infection. Using two clinically relevant Candida …

[HTML][HTML] Characterization of the oral fungal microbiome (mycobiome) in healthy individuals

MA Ghannoum, RJ Jurevic, PK Mukherjee, F Cui… - PLoS …, 2010 - journals.plos.org
The oral microbiome–organisms residing in the oral cavity and their collective genome–are
critical components of health and disease. The fungal component of the oral microbiota has …

Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins

…, PK Mukherjee, MA Ghannoum - Antimicrobial agents …, 2002 - Am Soc Microbiol
Biofilms, likely the predominant mode of device-related microbial infection, exhibit resistance
to antimicrobial agents. Evidence suggests that Candida biofilms have dramatically …

Antifungal resistance of candidal biofilms formed on denture acrylic in vitro

…, LL Hoyer, LJ Douglas, MA Ghannoum - Journal of dental …, 2001 - journals.sagepub.com
Denture biofilms represent a protective reservoir for oral microbes. The study of the biology
of Candida in these biofilms requires a reliable model. A reproducible model of C. albicans …

Antifungal susceptibility testing: practical aspects and current challenges

…, A Espinel-Ingroff, MA Ghannoum… - Clinical microbiology …, 2001 - Am Soc Microbiol
Development of standardized antifungal susceptibility testing methods has been the focus of
intensive research for the last 15 years. Reference methods for yeasts (NCCLS M27-A) and …

A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns

MA Ghannoum, RA Hajjeh, R Scher, N Konnikov… - Journal of the American …, 2000 - Elsevier
Background: Onychomycosis, a fungal infection of the nail bed, is responsible for up to 50%
of nail disorders. Although several surveys have been conducted in different parts of the …

Comparison of Biofilms Formed by Candidaalbicans and Candidaparapsilosis on Bioprosthetic Surfaces

…, J Chandra, PK Mukherjee, MA Ghannoum - Infection and …, 2002 - Am Soc Microbiol
Little is known about fungal biofilms, which may cause infection and antibiotic resistance. In
this study, biofilm formation by different Candida species, particularly Candidaalbicans and C…