The Rho GTPases mediate actin rearrangements that are likely to be required for the
numerous cell shape changes in a developing embryo. In a genetic screen for Rho signaling …

Purpose: Routine toothbrushing is the principal method by which individuals remove plaque
and control plaque-related diseases, such as periodontitis and caries. Oral health care …

Background Herceptin, a humanized antibody to HER‐2, is now utilized in the clinic for
metastatic breast cancer treatment. The response rate for HER‐2+ patients is only 30% and little …

Facioscapulohumeral muscular dystrophy is an autosomal dominant disorder resulting from
an unusual genetic mechanism. The mutation, a deletion of 3.3 kb subtelomeric repeats, …

A single Rho GTPase family member is capable of initiating several different processes,
including cell cycle regulation, cytokinesis, cell migration, and transcriptional regulation [1]. It is …

TYK2 is a JAK family protein tyrosine kinase activated in response to multiple cytokines,
including type I IFNs, IL-6, IL-10, IL-12, and IL-23. Extensive studies of mice that lack TYK2 …

The Rac and Cdc42 GTPases share several regulators and effectors, yet perform distinct
biological functions. The factors determining such specificity in vivo have not been identified. In …

NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple
TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in …

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as
psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2. Hit triage, …

The cDNA for one of the receptors for human tumor necrosis factor (TNF) has been isolated.
This cDNA encodes a protein of 455 amino acids that is divided into an extracellular domain …