A liquid chromatography-tandem mass spectrometry assay was developed and validated
for the nine oral anticancer agents alectinib, cobimetinib, lenvatinib, nintedanib, osimertinib, …

Crizotinib and alectinib are anaplastic lymphoma kinase (ALK)‐inhibitors indicated for the
treatment of ALK‐positive metastatic non‐small cell lung cancer (NSCLC). At the currently …

Correlations between increasing concentrations of circulating tumor DNA (ctDNA) in plasma
and disease progression have been shown. A nonlinear mixed effects model to describe …

Background Based on reassuring short-term foetal and maternal safety data, there is an
increasing trend to administer chemotherapy during the second and third trimesters of pregnancy…

In recent years new targeted small molecule kinase inhibitors have become available for
pediatric patients with cancer. Relationships between drug exposure and treatment response …

Background: For oral anticancer drugs, trough concentration (C min) is usually used as a
target in therapeutic drug monitoring (TDM). Recording of C min is highly challenging in …

Background: Adequate gentamicin peak concentrations (C max) are important for optimal
clinical efficacy. Within a critically ill patient, substantial variability in C max can occur over time…

Aim Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may
alter with increasing age, but results are conflicting. This study aims to compare exposure …

Background ModraDoc006 is an oral formulation of docetaxel, which is co‐administered
with the cytochrome P450 3A4 and P‐glycoprotein inhibitor ritonavir (r): ModraDoc006/r. …

Taking a leadership role, the Illinois Department of Public Health's Division of Oral Health
has helped to successfully integrate oral health professionals into the emergency medical …