User profiles for J. A. Janssen

Joseph AMJL Janssen

Associate Professor, Internal Medicine, Erasmus MC, Rotterdam
Verified email at erasmusmc.nl
Cited by 11905

Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation.

HJ Moshage, JA Janssen, JH Franssen… - The Journal of …, 1987 - Am Soc Clin Investig
Hypoalbuminemia in inflammatory disorders is not an infrequent finding. However, little is
known about albumin synthesis in these patients. In the present study we have measured the …

High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study

…, L Stolk, EHG Oei, JBJ van Meurs, JA Janssen… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE Individuals with type 2 diabetes have increased fracture risk despite higher
bone mineral density (BMD). Our aim was to examine the influence of glucose control on …

Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index

…, P Arp, W Ester, JA Janssen… - Clinical …, 2003 - Wiley Online Library
objective Sensitivity to glucocorticoids differs between individuals, partially due to genetic
variation in the glucocorticoid receptor (GR) gene. We studied the sequence alteration of a …

Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies

…, S Rinaldi, E Riboli, R Kaaks, JA Janssen… - Annals of internal …, 2008 - acpjournals.org
Background: Some, but not all, published results have shown an association between
circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (…

A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels

…, NATM Huizenga, AG Uitterlinden, JA Janssen… - Diabetes, 2002 - Am Diabetes Assoc
We investigated whether a polymorphism in codons 22 and 23 of the glucocorticoid (GC)
receptor gene [GAGAGG(GluArg) → GAAAAG(GluLys)] is associated with altered GC sensitivity…

A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction

N Vaessen, P Heutink, JA Janssen, JCM Witteman… - Diabetes, 2001 - Am Diabetes Assoc
Evidence is accumulating that low levels of IGF-I play a role in the pathogenesis of type 2
diabetes and cardiovascular diseases. We examined the role of a genetic polymorphism in the …

Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes

…, PJD Delhanty, LJ Hofland, JA Janssen… - The Journal of …, 2005 - academic.oup.com
Ghrelin exerts various metabolic activities, including regulation of glucose levels in humans.
To verify whether the glucose response to ghrelin reflects a modulation of an insulin-…

[HTML][HTML] Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer

JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia …

The effect of host size on quality attributes of the egg parasitoid, Trichogramma pretiosum

…, L Forster, B Stephens, JAM Janssen - Entomologia …, 1992 - Wiley Online Library
In a study of the quality of Trichogramma pretiosum Riley (Hymenoptera: Trichogrammidae),
we compared female wasps emerging from natural hosts, parasitized in the laboratory or …

Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight

N Vaessen, JA Janssen, P Heutink, A Hofman… - The Lancet, 2002 - thelancet.com
Low birthweight is associated with later risk of type 2 diabetes and related disorders. We aimed
to show that a polymorphism in the gene for insulin-like growth factor-l, which has proved …