Background We compared transcatheter aortic-valve replacement (TAVR), using a self-expanding
transcatheter aortic-valve bioprosthesis, with surgical aortic-valve replacement in …

1 Purpose These reporting guidelines are intended to facilitate analysis and reporting of clinical
results of various therapeutic approaches to diseased heart valves such that meaningful …

Background Patisiran, an investigational RNA interference therapeutic agent, specifically
inhibits hepatic synthesis of transthyretin. Methods In this phase 3 trial, we randomly assigned …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH, autoimmune
hepatitis; ALF, acute liver failure; ALT, alanine aminotransferase; AMA, antimitochondrial …

Background Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory
properties. This study evaluates the efficacy and safety of baricitinib in combination …

Background Transcatheter aortic-valve replacement (TAVR) is an alternative to surgery in
patients with severe aortic stenosis who are at increased risk for death from surgery; less is …

In retrospect it is not surprising that reformers should look to schools as central to the solution
of the Indian problem. As an instrument for fostering social cohesion and republicanism, no …

Background Although transcatheter aortic-valve replacement (TAVR) is an accepted alternative
to surgery in patients with severe aortic stenosis who are at high surgical risk, less is …

Background Atrial fibrillation (AF) after coronary artery bypass surgery (CABG) is the most
common sustained arrhythmia. Its pathophysiology is unclear, and its prevention and …

The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale …