Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.

DM Bowen, CB Smith, P White… - Brain: a journal of …, 1976 - europepmc.org
Fifty-six brains from middle-aged and elderly normal as well as demented subjects and
patients with provisional clinical diagnosis of other neurological and psychiatric diseases were …

Alzheimer's disease: correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities

GK Wilcock, MM Esiri, DM Bowen, CCT Smith - Journal of the neurological …, 1982 - Elsevier
We have examined the choline acetyltransferase [CAT] activity in autopsy samples of frontal
and temporal lobe cortex from 47 patients (31 with Alzheimer's disease, 4 with dementia due …

Presynaptic cholinergic dysfunction in patients with dementia

NR Sims, DM Bowen, SJ Allen… - Journal of …, 1983 - Wiley Online Library
Indices of presynaptic cholinergic nerve endings were assayed in neocortical biopsy samples
from patients with presenile dementia. For those patients in whom Alzheimer's disease …

Biochemical assessment of serotonergic and cholinergic dysfunction and cerebral atrophy in Alzheimer's disease

DM Bowen, SJ Allen, JS Benton… - Journal of …, 1983 - Wiley Online Library
Markers of serotonin synapses in entire temporal lobe and frontal and temporal neocortex
were examined for changes in Alzheimer's disease by use of both neurosurgical and autopsy …

Polymersome carriers: from self-assembly to siRNA and protein therapeutics

DA Christian, S Cai, DM Bowen, Y Kim… - European Journal of …, 2009 - Elsevier
Polymersomes are polymer-based vesicular shells that form upon hydration of amphiphilic
block copolymers. These high molecular weight amphiphiles impart physicochemical …

Neocortical cholinergic neurons in elderly people

…, CR Hiley, LH Carrasco, IEI Williams, DM Bowen - The Lancet, 1977 - Elsevier
… Retrospective analysis of our tumour records has revealed another patient with a pancreatic
D-cell tumour and achlorhydria, steatorrhoea, and diabetes mellitus. The symptoms may be …

Neurochemical studies of early-onset Alzheimer's disease: possible influence on treatment

…, AM Palmer, NR Sims, DM Bowen… - … England Journal of …, 1985 - Mass Medical Soc
Multiple neurotransmitter deficits found in recent autopsy studies of patients with Alzheimer's
disease may militate against the success of "simple cholinergic replacement" as treatment. …

Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease

…, GK Wilcock, MM Esiri, PT Francis, DM Bowen - Brain research, 1987 - Elsevier
… and Bowen, DM, Binding of the novel serotonin agonist 8-hydroxy-2(di-n-propylamino) tetralin
in normal … 31 Palmer, AM, Francis, PT and Bowen, DM, Stability of noradrenaline and 5-…

Presynaptic serotonergic dysfunction in patients with Alzheimer's disease

…, D Neary, JS Snowden, DM Bowen - Journal of …, 1987 - Wiley Online Library
Indices of presynaptic serotonergic nerve endings were assayed in neocortical biopsy
samples from patients with histologically verified Alzheimer's disease. The concentrations of 5‐…

Alzheimer's disease: a correlative study.

…, JS Snowden, DM Mann, DM Bowen… - Journal of Neurology …, 1986 - jnnp.bmj.com
In a study of 17 patients with histologically proven Alzheimer's disease the relationship between
psychological, pathological and chemical measures of disorder was examined. Severity …