Purpose Recent data showed improvement in progression-free survival (PFS) when adding
everolimus to exemestane in patients with advanced breast cancer experiencing recurrence/…

Objective To evaluate levels of biomarkers in preclinical rheumatoid arthritis (RA) and to
use elevated biomarkers to develop a model for the prediction of time to future diagnosis of …

Objectives: To investigate factors that may influence the prevalence and timing of appearance
of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies during …

The α-synuclein protein can adopt several different conformations that cause
neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: …

Background. Varicella-zoster virus (VZV)-specific cell-mediated immunity is important for
protection against VZV disease. We studied the relationship between VZV cell-mediated …

BACKGROUND: Trauma is the number one cause of maternal death during pregnancy, but
incidence of fetal loss exceeds maternal loss by more than 3 to 1. We hypothesized that we …

The discovery of biomarkers that predict treatment effectiveness has great potential for improving
medical care, particularly in oncology. These biomarkers are increasingly reported on a …

Objective Intradiscal biologic therapy is a promising strategy for managing intervertebral
disc degeneration. However, these therapies require a rich nutrient supply, which may be …

The current policy for determining priority for organ allocation is based on the model for end
stage liver disease (MELD). We hypothesize that severity of graft dysfunction assessed by …

To describe the international landscape of clinical trials in carbon‐ion radiotherapy (CIRT),
the authors reviewed the current status of 63 ongoing clinical trials (median, 47 participants) …