The development of a portfolio of COVID-19 vaccines to vaccinate the global population
remains an urgent public health imperative 1 . Here we demonstrate the capacity of a subunit …

Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide 1 .
The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has …

… educator Alex. W. White has assembled a wealth of information and examples in his
exploration of what makes visual design stunning and easy to read. Readers will discover White's …

The nuclear enzyme poly(ADP-ribose) polymerase (PARP) facilitates the repair of DNA strand
breaks and is implicated in the resistance of cancer cells to certain DNA-damaging agents…

Nucleoside reverse transcriptase inhibitors (NRTIs) remain the cornerstone of highly active
antiretroviral therapy (HAART) combination regimens. However, it has been known for some …

Potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate
the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of two novel …

Background We aimed to assess efficacy and safety, with a special focus on cardiovascular
safety, of the novel dual GIP and GLP-1 receptor agonist tirzepatide versus insulin glargine …

Objective— Although atherosclerosis is associated with systemic risk factors such as age,
high cholesterol, and obesity, plaque formation occurs predominately at branches and bends …

The parathyroid hormone receptor-1 (PTH1R) is a class BG protein–coupled receptor central
to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism. …

Background The identification of people at risk of cognitive impairment is essential for improving
recruitment in secondary prevention trials of Alzheimer's disease. We aimed to test and …