Abstract
Optimal management of complex autoimmune diseases requires a multidisciplinary medical team including dentists to care for lesions of the oral cavity. In this review, we discuss the presentation, prevalence, diagnosis, and treatment of oral manifestations in chronic graft-versus-host disease (cGVHD), which is a major late complication in patients treated by allogeneic hematopoietic stem cell transplantation. We assess current general knowledge of systemic and oral cGVHD and present general treatment recommendations based on literature review and our clinical experience. Additionally, we review areas where the understanding of oral cGVHD could be improved by further research and address tools with which to accomplish the long-term goal of providing better health and quality of life to patients with cGVHD.
Published 2012. This article is a US Government work and is in the public domain in the USA.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Autoimmune Diseases* / drug therapy
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Autoimmune Diseases* / etiology
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B-Lymphocytes / physiology
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Carcinoma, Squamous Cell / etiology
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Chronic Disease
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Dendritic Cells / physiology
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Graft vs Host Disease* / complications
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Graft vs Host Disease* / drug therapy
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Graft vs Host Disease* / etiology
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Graft vs Host Disease* / immunology
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Graft vs Host Disease* / pathology
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Hematopoietic Stem Cell Transplantation / adverse effects*
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Humans
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Immunosuppressive Agents / therapeutic use
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Mouth Diseases* / complications
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Mouth Diseases* / drug therapy
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Mouth Diseases* / etiology
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Mouth Diseases* / immunology
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Mouth Diseases* / pathology
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Mouth Mucosa / pathology
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Mouth Neoplasms / etiology
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Range of Motion, Articular
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Salivary Glands / pathology
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Salivary Proteins and Peptides / physiology
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T-Lymphocytes / physiology
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Xerostomia / etiology
Substances
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Immunosuppressive Agents
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Salivary Proteins and Peptides