Etiology and Pathogenesis of Periodontal Diseases
Section snippets
Etiology and pathogenesis of periodontal diseases
Gingivitis and periodontitis are inflammatory conditions of infectious nature [2]. The unequivocal role of dental bacterial plaque in the development of these diseases was established almost 40 years ago [3], [4], [5], [6], [7]. Gingivitis is a reversible inflammatory reaction of the marginal gingiva to plaque accumulation, whereas periodontitis is a destructive, nonreversible condition resulting in loss of tooth connective-tissue attachment to bone, which ultimately leads to loss of the
Summary
The last decade or so has brought significant advances to the understanding of periodontal disease pathogenesis. These advances include the discovery of new, uncultivated, disease-associated bacterial species; the recognition of dental plaque as a biofilm; the identification and characterization of genetic defects that predispose to periodontitis; the role of risk factors in disease susceptibility; and the discovery of new host-derived cellular and molecular mechanisms implicated in periodontal
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This work was supported by the Section of Periodontology, College of Dentistry, The Ohio State University.