Etiology and Pathogenesis of Periodontal Diseases

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Etiology and pathogenesis of periodontal diseases

Gingivitis and periodontitis are inflammatory conditions of infectious nature [2]. The unequivocal role of dental bacterial plaque in the development of these diseases was established almost 40 years ago [3], [4], [5], [6], [7]. Gingivitis is a reversible inflammatory reaction of the marginal gingiva to plaque accumulation, whereas periodontitis is a destructive, nonreversible condition resulting in loss of tooth connective-tissue attachment to bone, which ultimately leads to loss of the

Summary

The last decade or so has brought significant advances to the understanding of periodontal disease pathogenesis. These advances include the discovery of new, uncultivated, disease-associated bacterial species; the recognition of dental plaque as a biofilm; the identification and characterization of genetic defects that predispose to periodontitis; the role of risk factors in disease susceptibility; and the discovery of new host-derived cellular and molecular mechanisms implicated in periodontal

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References (164)

  • E. Theilade et al.

    Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation

    J Periodontal Res

    (1966)
  • J. Lindhe et al.

    Experimental periodontitis in the beagle dog

    J Periodontal Res

    (1973)
  • J. Slots et al.

    Longitudinal study of experimentally induced periodontal disease in Macaca arctoides: relationship between microflora and alveolar bone loss

    Infect Immun

    (1979)
  • S.C. Holt et al.

    Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis

    Science

    (1988)
  • M.A. Listgarten et al.

    3-year longitudinal study of the periodontal status of an adult population with gingivitis

    J Clin Periodontol

    (1985)
  • H. Löe et al.

    Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age

    J Clin Periodontol

    (1986)
  • R.C. Page

    Milestones in periodontal research and the remaining critical issues

    J Periodontal Res

    (1999)
  • W.J. Loesche et al.

    Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment

    Clin Microbiol Rev

    (2001)
  • W.J. Loesche

    Chemotherapy of dental plaque infections

    Oral Sci Rev

    (1976)
  • E. Theilade et al.

    Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation

    J Periodontal Res

    (1966)
  • A. Mombelli et al.

    Microbial changes associated with the development of puberty gingivitis

    J Periodontal Res

    (1990)
  • J.M. Goodson et al.

    Patterns of progression and regression of advanced destructive periodontal disease

    J Clin Periodontol

    (1982)
  • I. Kroes et al.

    Bacterial diversity within the human subgingival crevice

    Proc Natl Acad Sci USA

    (1999)
  • B.J. Paster et al.

    Bacterial diversity in human subgingival plaque

    J Bacteriol

    (2001)
  • B.K. Choi et al.

    Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive periodontitis

    Infect Immun

    (1994)
  • J.W. Costerton

    Overview of microbial biofilms

    J Ind Microbiol

    (1995)
  • E. Isogai et al.

    Bacterial adherence to gingival epithelial cells of rats with naturally occurring gingivitis

    J Periodontol

    (1986)
  • H.F. Jenkinson et al.

    Streptococcal adhesion and colonization

    Crit Rev Oral Biol Med

    (1997)
  • P.E. Kolenbrander

    Oral microbial communities: biofilms, interactions, and genetic systems

    Annu Rev Microbiol

    (2000)
  • P.E. Kolenbrander et al.

    Communication among oral bacteria [table of contents]

    Microbiol Mol Biol Rev

    (2002)
  • W.O. Chung et al.

    Signaling system in Porphyromonas gingivalis based on a LuxS protein

    J Bacteriol

    (2001)
  • K.P. Fong et al.

    Intra- and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS

    Infect Immun

    (2001)
  • R.J. Lamont et al.

    Role of the Streptococcus gordonii SspB protein in the development of Porphyromonas gingivalis biofilms on streptococcal substrates

    Microbiol

    (2002)
  • R. McNab et al.

    LuxS-based signaling in Streptococcus gordonii: autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis

    J Bacteriol

    (2003)
  • Y.H. Li et al.

    Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans

    J Bacteriol

    (2002)
  • Y.H. Li et al.

    A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation

    J Bacteriol

    (2002)
  • P.S. Stewart

    Diffusion in biofilms

    J Bacteriol

    (2003)
  • C.G. Dowson et al.

    Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae

    Proc Natl Acad Sci USA

    (1990)
  • A.P. Roberts et al.

    Transfer of TN916-like elements in microcosm dental plaques

    Antimicrob Agents Chemother

    (2001)
  • H. Anwar et al.

    Testing the susceptibility of bacteria in biofilms to antibacterial agents

    Antimicrob Agents Chemother

    (1990)
  • P.E. Kolenbrander et al.

    Effect of saliva on coaggregation of oral Actinomyces and Streptococcus species

    Infect Immun

    (1984)
  • L.D. Du et al.

    Identification of saliva-regulated genes of Streptococcus gordonii DL1 by differential display using random arbitrarily primed PCR

    Infect Immun

    (2000)
  • Y. Li et al.

    Regulation of the gtfBC and ftf genes of Streptococcus mutans in biofilms in response to pH and carbohydrate

    Microbiol

    (2001)
  • H. Ohta et al.

    The relationships between leukotoxin production, growth rate and the bicarbonate concentration in a toxin-production-variable strain of Actinobacillus actinomycetemcomitans

    Microbiol

    (1996)
  • P.D. Marsh et al.

    The effect of growth rate and haemin on the virulence and proteolytic activity of Porphyromonas gingivalis W50

    Microbiol

    (1994)
  • J.J. Zambon et al.

    Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease

    Infect Immun

    (1983)
  • F. Goulhen et al.

    Oral microbial heat-shock proteins and their potential contributions to infections

    Crit Rev Oral Biol Med

    (2003)
  • K. Yamazaki et al.

    Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients

    Infect Immun

    (2002)
  • K. Ueki et al.

    Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease

    Clin Exp Immunol

    (2002)
  • T. Njoroge et al.

    A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells

    Infect Immun

    (1997)
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    This work was supported by the Section of Periodontology, College of Dentistry, The Ohio State University.

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