Abstract
Purpose: The aim of this investigation through post-hoc analyses was to determine the ability to achieve gingival health in the short term with daily rinsing with an essential oil containing antimicrobial mouthrinse.
Methods: Conventional Analysis of Covariance (ANCOVA) on whole mouth mean plaque and gingivitis scores were originally conducted to demonstrate efficacy of adjunctive use of Cool Mint® LISTERINE® Antiseptic (EO) compared to negative control [brushing (B) or brushing/flossing (BF)] in each of 5 studies containing a 4 week evaluation. The Modified Gingival Index (MGI) was split into 2 categories: healthy (scores 0, 1) and unhealthy (≥2). Data, reflecting subjects that completed 4 weeks of treatment from 5 studies, were evaluated to determine the mean percent of healthy sites and mean percent of more inflamed “affected” areas (MGI≥3).
Results: At baseline, the mean percent healthy gingival sites ranged from 0.1 to 3.2%. At 4 weeks, up to 29.3% and 16.1% of sites were healthy for the EO group and negative control group, respectively. Three and 6 month data from 2 of the 5 studies resulted in up to 39.6% and 62% at 3 and 6 month mean percent healthy sites per subject for EO and up to 17.2% and 15.6% at 3 and 6 months, respectively, for negative control. Virtually plaque free sites (PI =0, 1) at 4 weeks ranged up to 34.3% and 8.1% for EO and control groups, respectively.
Conclusion: Significantly more healthy gingival sites and virtually plaque free tooth surfaces can be achieved as early as 4 weeks with use of an essential oil antimicrobial mouthrinse. This finding continues through 6 months twice daily use as part of oral care practices compared to mechanical oral hygiene alone.
Footnotes
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Christine A Charles, RDH, BA, is the Director, Clinical Research, Department of Clinical Operations; Toni Anne Lisante BA is a Manager of Clinical Research; Ratna Revankar PhD is Director, Global Biostatistics. All three are at Johnson & Johnson Consumer & Personal Products Worldwide, Morris Plains, New Jersey. Jose Roberto Cortelli, PhD, is an Associate Professor; Sheila Cavalca Cortelli, DDS, PhD, is an Associate Professor; Davi Aquino, PhD, is an Assistant Professor. All three are at the Nucleus of Periodontal Research, University of Taubaté (UNITAU), São Paulo, Brazil. At the time this research was conducted, Chhaju R. Goyal, BDS, was an Associate Research Dentist at Bio Sci Research Canada Ltd. Mississauga, Ontario, Canada, and Pejmon Amini, DDS, was a clinical examiner at Bio Sci Research America Inc. Las Vegas, Nevada.
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This study supports the NDHRA priority area, Health Promotion/Disease Prevention: Investigate the effectiveness of oral self-care behaviors that prevent or reduce oral diseases among all age, social and cultural groups.
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Disclosure
These 5 clinical studies were sponsored by Johnson & Johnson Consumer and Personal Products Worldwide Division of Johnson & Johnson Consumer Companies, Inc. Authors Revankar, Lisante and Charles are employed by Johnson & Johnson Consumer and Personal Products Worldwide Division of Johnson & Johnson Consumer Companies, Inc. Authors JR Cortelli and S Cortelli serve as consultants to Johnson & Johnson do Brasil Industria e Comercio de Produtos para Saude Ltda.
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